Effect of auditory cortex lesions on NADPH-diaphorase staining in the inferior colliculus of rat
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- barvení a značení MeSH
- histocytochemie metody MeSH
- krysa rodu Rattus MeSH
- NADPH-dehydrogenasa metabolismus MeSH
- nemoci mozku enzymologie patologie patofyziologie MeSH
- neurony enzymologie MeSH
- neuropil enzymologie MeSH
- potkani Long-Evans MeSH
- referenční hodnoty MeSH
- sluchové korové centrum patofyziologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- NADPH-dehydrogenasa MeSH
Projections from the auditory cortex (AC) in the rat terminate in the dorsal cortex (DC) and in the external cortex (EC) of the inferior colliculus (IC), areas which exhibit a moderate number of nicotinamide-adenine dinucleotide phosphate-diaphorase (NADPH-d) positive neurons. NADPH-d co-localizes with nitric oxide synthase, which is responsible for the production of the transcellular messenger, nitric oxide. Changes in NADPH-d staining in the IC were found after unilateral lesions of the AC. Lesions resulted in a reduction in NADPH-d staining in neurons and neuropil within the ipsilateral DC and EC with the maximum reduction occurring 3-4 days after lesion. The reduction in NADPH-d staining in the contralateral IC was less pronounced. Lesions affecting auditory areas Te 1 and Te 3 produced the largest decrease in NADPH-d staining in neurons and neuropil. This finding may be related to the abolition of the influence of glutamatergic corticocollicular and commissural pathways.
Citace poskytuje Crossref.org
Immunocytochemical profiles of inferior colliculus neurons in the rat and their changes with aging
