Excitability changes of cortical neurons during the postnatal period in rats exposed to prenatal hypobaric hypoxia
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
11522050
Knihovny.cz E-zdroje
- MeSH
- atmosférický tlak MeSH
- elektrofyziologie MeSH
- epilepsie patofyziologie MeSH
- hypoxie patofyziologie MeSH
- krysa rodu Rattus MeSH
- motorické korové centrum cytologie patofyziologie MeSH
- nadmořská výška MeSH
- neurony fyziologie MeSH
- novorozená zvířata MeSH
- somatosenzorické korové centrum cytologie patofyziologie MeSH
- těhotenství MeSH
- zpožděný efekt prenatální expozice * MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Pregnant rats were exposed to intermittent hypobaric hypoxia (at a simulated altitude of 7000 m or 5000 m) and the excitability of cortical neurons of their pups was tested. Stimulation of the sensorimotor cortex of rats prenatally exposed to hypoxia shortened the duration of cortical afterdischarges in 12-day-old rats, but did not change the excitability in 25-day-old animals. Shortening of the first afterdischarge in 35-day-old rats but the prolongation of the first afterdischarge in adult rats (as compared to the duration of cortical afterdischarges in rats not exposed to prenatal hypoxia) were registered. The possible mechanisms of different excitability of cortical neurons in rats prenatally exposed to hypobaric hypoxia are discussed.
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Impact of perinatal hypoxia on the developing brain
