Excitability changes of cortical neurons during the postnatal period in rats exposed to prenatal hypobaric hypoxia
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11522050
Knihovny.cz E-resources
- MeSH
- Atmospheric Pressure MeSH
- Electrophysiology MeSH
- Epilepsy physiopathology MeSH
- Hypoxia physiopathology MeSH
- Rats MeSH
- Motor Cortex cytology physiopathology MeSH
- Altitude MeSH
- Neurons physiology MeSH
- Animals, Newborn MeSH
- Somatosensory Cortex cytology physiopathology MeSH
- Pregnancy MeSH
- Prenatal Exposure Delayed Effects * MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Pregnant rats were exposed to intermittent hypobaric hypoxia (at a simulated altitude of 7000 m or 5000 m) and the excitability of cortical neurons of their pups was tested. Stimulation of the sensorimotor cortex of rats prenatally exposed to hypoxia shortened the duration of cortical afterdischarges in 12-day-old rats, but did not change the excitability in 25-day-old animals. Shortening of the first afterdischarge in 35-day-old rats but the prolongation of the first afterdischarge in adult rats (as compared to the duration of cortical afterdischarges in rats not exposed to prenatal hypoxia) were registered. The possible mechanisms of different excitability of cortical neurons in rats prenatally exposed to hypobaric hypoxia are discussed.
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