The human endogenous retroviruses database (HERVd) is maintained at the Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, and is accessible via the World Wide Web at http://herv.img.cas.cz. The HERVd provides complex information on and analysis of retroviral elements found in the human genome. It can be used for searches of individual HERV families, identification of HERV parts, graphical output of HERV structures, comparison of HERVs and identification of retrovirus integration sites.

Institute of Molecular Genetics Academy of Sciences of the Czech Republic Flemingovo 2 CZ 16637 Prague Czech Republic

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Smit A.F. (1999) Interspersed repeats and other mementos of transposable elements in mammalian genomes. Curr. Opin. Genet. Dev., 9, 657–663. PubMed

International Human Genome Sequencing Consortium (2001) Initial sequencing and analysis of the human genome. Nature, 409, 860–921. PubMed

Venter J.D., Adams,M.D., Myers,E.W., Li,P.W., Mural,R.J., Sutton,G.G., Smith,H.O., Yandell,M., Evans,C.A. and Holt,R.A. et al. (2001) The sequence of the human genome. Science, 291, 1304–1351. PubMed

Wilkinson D. (1994) Human endogenous retroviruses. In Levy,J.A. (ed.), The Retoviriadae. Plenum Press, New York, NY, Vol. 3, pp. 465–553.

Sverdlov E.D. (2000) Retroviruses and primate evolution. Bioessays, 22, 161–171. PubMed

Brosius J. (1999) RNAs from all categories generate retrosequences that may be exapted as novel genes or regulatory elements. Gene, 238, 115–134. PubMed

Schon U., Seifarth,W., Baust,C., Hohenadl,C., Erfle,V. and Leib-Mosch,C. (2001) Cell type-specific expression and promoter activity of human endogenous retroviral long terminal repeats. Virology, 279, 280–291. PubMed

Mi S., Lee,X., Li,X., Veldman,G.M., Finnerty,H., Racie,L., LaVallie,E., Tang,X.Y., Edouard,P., Howes,S., Keith,J.C.,Jr and McCoy,J.M. (2000) Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis. Nature, 403, 785–789. PubMed

Blond J.L., Lavillette,D., Cheynet,V., Bouton,O., Oriol,G., Chapel-Fernandes,S., Mandrand,B., Mallet,F. and Cosset,F.L. (2000) An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor. J. Virol., 74, 3321–3329. PubMed PMC

Lower R. (1999) The pathogenic potential of endogenous retroviruses: facts and fantasies. Trends Microbiol., 7, 350–356. PubMed

Perron H., Garson,J.A., Bedin,F., Beseme,F., Paranhos-Baccala,G., Komurian-Pradel,F., Mallet,F., Tuke,P.W., Voisset,C. and Blond,J.L. (1997) Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis. Proc. Natl Acad. Sci. USA, 94, 7583–7588. PubMed PMC

Karlsson H., Bachmann,X., Silke,B., Johannes,S., Justin,McA., Torrey,E.F. and Yolken,R.H. (2001) Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophrenia. Proc. Natl Acad. Sci. USA, 98, 4634–4639. PubMed PMC

Griffiths D.J. (2001) Endogenous retroviruses in the human genome sequence. Genome Biol., 2, 1017.1–1017.3. PubMed PMC

Jurka J. (1998) Repeats in genomic DNA: mining and meaning. Curr. Opin. Struct. Biol., 8, 333–337. PubMed

Jurka J. (2000) Repbase update: a database and an electronic journal of repetitive elements. Trends Genet., 9, 418–420. PubMed

Eddy S.R. (1998) Profile hidden Markov models. Bioinformatics, 14, 755–763. PubMed

HERVd: the Human Endogenous RetroViruses Database: update

Processed pseudogenes of human endogenous retroviruses generated by LINEs: their integration, stability, and distribution