MRP 8/14 and procalcitonin serum levels in organ transplantations
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11803621
Knihovny.cz E-resources
- MeSH
- Biomarkers blood MeSH
- Antigens, Differentiation blood MeSH
- Dimerization MeSH
- Calcitonin blood MeSH
- Calgranulin A MeSH
- Calgranulin B MeSH
- Middle Aged MeSH
- Humans MeSH
- Calcitonin Gene-Related Peptide MeSH
- Protein Precursors blood MeSH
- S100 Proteins blood MeSH
- Calcium-Binding Proteins blood MeSH
- Reference Values MeSH
- Aged MeSH
- Organ Transplantation physiology MeSH
- Inflammation MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers MeSH
- CALCA protein, human MeSH Browser
- Antigens, Differentiation MeSH
- Calcitonin MeSH
- Calgranulin A MeSH
- Calgranulin B MeSH
- Calcitonin Gene-Related Peptide MeSH
- Protein Precursors MeSH
- S100 Proteins MeSH
- Calcium-Binding Proteins MeSH
OBJECTIVES: MRP8/14 is a heterodimer of two myeloid calcium-binding proteins associated with different types of acute inflammatory processes. We studied MRP8/14 together with procalcitonin (PCT) serum levels in order to diagnose infectious complications or the rejection process affecting kidney or heart allograft. METHODS: A total of 419 serum samples was evaluated. MRP8/14 levels were measured by ELISA (BMA Biomed), PCT by a sensitive immunoluminiscent assay ILMA (Brahms Diagn.) RESULTS: Both parameters showed very low basal levels in healthy subjects (range 303-1,660 ng/ml of MRP8/14; less than 0.08 ng/ml of PCT). A rapid increase in serum levels occurred in response to bacterial infections (MRP8/14 up to 6,230 ng/ml; PCT up to 297 ng/ml). Serum PCT concentration remained low in the presence of kidney allograft rejection, where MRP8/14 levels were increased. An uncomplicated outcome of kidney or heart transplantation did not change basal serum MRP8/14 and PCT levels. CONCLUSIONS: We conclude that 1) both MRP8/14 and PCT are very sensitive markers of complications in organ transplant recipients (normal values in uncomplicated outcome) 2) combination of both parameters is useful to discriminate between rejection (increased MRP8/14 with normal PCT) and systemic bacterial infection (both parameters increased).
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