Relationship between insulin resistance and muscle triglyceride content in nonobese and obese experimental models of insulin resistance syndrome
Language English Country United States Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
12079872
Knihovny.cz E-resources
- MeSH
- Species Specificity MeSH
- Glucose Tolerance Test MeSH
- Insulin Resistance * MeSH
- Rats MeSH
- Disease Models, Animal * MeSH
- Obesity metabolism MeSH
- Muscles metabolism MeSH
- Triglycerides metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Triglycerides MeSH
In nonobese hereditary hypertriglyceridemic (HTg) rats and obese HTg Koletsky SHROB/Kol rats, muscle triglyceride accumulation and its relationship to glucose homeostasis and tissue sensitivity to insulin action were examined. Soleus muscle and diaphragm triglyceride contents were markedly increased in HTg rats as compared with controls and were further increased in obese animals. On the other hand, glucose intolerance and impairment of insulin-stimulated in vitro glycogen synthesis were of a similar degree in nonobese as well as obese animals. Results indicate that insulin resistance did not increase proportionally to muscle triglyceride content.
