Relationship between insulin resistance and muscle triglyceride content in nonobese and obese experimental models of insulin resistance syndrome
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
12079872
Knihovny.cz E-zdroje
- MeSH
- druhová specificita MeSH
- glukózový toleranční test MeSH
- inzulinová rezistence * MeSH
- krysa rodu Rattus MeSH
- modely nemocí na zvířatech * MeSH
- obezita metabolismus MeSH
- svaly metabolismus MeSH
- triglyceridy metabolismus MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- triglyceridy MeSH
In nonobese hereditary hypertriglyceridemic (HTg) rats and obese HTg Koletsky SHROB/Kol rats, muscle triglyceride accumulation and its relationship to glucose homeostasis and tissue sensitivity to insulin action were examined. Soleus muscle and diaphragm triglyceride contents were markedly increased in HTg rats as compared with controls and were further increased in obese animals. On the other hand, glucose intolerance and impairment of insulin-stimulated in vitro glycogen synthesis were of a similar degree in nonobese as well as obese animals. Results indicate that insulin resistance did not increase proportionally to muscle triglyceride content.
