Vibration-induced white finger (VWF) is secondary Raynaud's phenomenon caused by vibrating hand tools. Initially described in 1911 by Loriga, the pathophysiology of VWF remains unclear. This review attempts to summarize the current common and the most modern theories of the pathogenesis of VWF and propose a model of multifactorial etiology. The role of vasoregulatory abnormalities--autonomic dysfunction, local vasoregulatory abnormalities, of the endothelial cell control, of hemostasis, fibrinolysis and hemorrheology, of the leukocyte activation and the levels cell adhesion molecules and pro-inflammatory cytokines have been reviewed.

Department of Hygiene and Ecology Medical University Dimitar Nestorov 15 Blvd 1431 Sofia Bulgaria