Seronegative Lyme arthritis caused by Borrelia garinii
Language English Country Germany Media print
Document type Case Reports, Journal Article
PubMed
12189466
DOI
10.1007/s100670200087
Knihovny.cz E-resources
- MeSH
- Antigens, Bacterial blood MeSH
- Borrelia burgdorferi Group genetics immunology pathogenicity MeSH
- Cephalosporins therapeutic use MeSH
- Ceftriaxone therapeutic use MeSH
- DNA, Bacterial analysis MeSH
- Adult MeSH
- Humans MeSH
- Lyme Disease drug therapy immunology pathology MeSH
- Sulfasalazine therapeutic use MeSH
- Synovial Fluid microbiology MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Names of Substances
- Antigens, Bacterial MeSH
- Cephalosporins MeSH
- Ceftriaxone MeSH
- DNA, Bacterial MeSH
- Sulfasalazine MeSH
A case of a female patient suffering from Lyme arthritis (LA) without elevated antibody levels to Borrelia burgdorferi sensu lato is reported. Seronegative Lyme arthritis was diagnosed based on the classic clinical manifestations and DNA-detected Borrelia garinii in blood and synovial fluid of the patient, after all other possible causes of the disease had been ruled out. The disease was resistant to the first treatment with antibacterial agents. Six months after the therapy, arthritis still persisted and DNA of Borrelia garinii was repeatedly detected in the synovial fluid and the tissue of the patient. At the same time, antigens or parts of spirochaetes were detected by electron microscopy in the synovial fluid, the tissue and the blood of the patient. The patient was then repeatedly treated by antibiotics and synovectomy has been performed.
References provided by Crossref.org
Synovial fluid alpha-defensins in Lyme arthritis-a useful marker
