Dystonia: a disorder of motor programming or motor execution?
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
12465050
DOI
10.1002/mds.10284
Knihovny.cz E-zdroje
- MeSH
- dystonie diagnóza patofyziologie MeSH
- elektrodiagnostika MeSH
- kosterní svaly inervace MeSH
- lidé MeSH
- motorické neurony fyziologie MeSH
- mozková kůra patofyziologie MeSH
- nervosvalová vřeténka patofyziologie MeSH
- nervové analyzátory patofyziologie MeSH
- nervové dráhy patofyziologie MeSH
- nervový útlum fyziologie MeSH
- somatosenzorické korové centrum patofyziologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
For some time, dystonia has been seen as purely a motor disorder. Relatively novel concepts published approximately 10 years ago also presumed that in the development of dystonic dyskinesias, only motor behaviour was abnormal. Neurophysiological observations of various types of dystonic disorders, which were performed using sophisticated electromyography, polymyography, H-reflex examination, long-latency reflex, etc., as well as new insights into the behaviour of dystonia, have urged the inclusion of sensory (particularly somatosensory) mechanisms into the pathophysiological background of dystonia. The major role has been considered to be played by abnormal proprioceptive input by means of the Ia proprioceptive afferents, with the source of this abnormality found in the abnormal processing of muscle spindle afferent information. However, neurophysiological investigations have also provided evidence that the abnormality in the central nervous system is located not only at the spinal and subcortical level, but also at the cortical level; specifically, the cortical excitability and intracortical inhibition have been revealed as abnormal. This evidence was revealed by SEP recordings, paired transcranial magnetic stimulation recordings, and BP and CNV recordings. The current concept of dystonic movement connects the abnormal function of somatosensory pathways and somatosensory analysers with the dystonic performance of motor action, which is based on the abnormality of sensorimotor integration.
Citace poskytuje Crossref.org
Contemporary clinical neurophysiology applications in dystonia