3-nitrotyrosin--indikátor zmĕn tvorby reaktivních sloucenin kyslíku a dusíku
[3-nitrotyrosine--an indicator of changes in the formation of reactive oxygen and nitrogen species]
Jazyk čeština Země Česko Médium print
Typ dokumentu anglický abstrakt, časopisecké články, práce podpořená grantem, přehledy
PubMed
12608109
- MeSH
- biologické markery analýza MeSH
- lidé MeSH
- reaktivní formy dusíku biosyntéza MeSH
- reaktivní formy kyslíku metabolismus MeSH
- tyrosin analogy a deriváty analýza MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- 3-nitrotyrosine MeSH Prohlížeč
- biologické markery MeSH
- reaktivní formy dusíku MeSH
- reaktivní formy kyslíku MeSH
- tyrosin MeSH
3-nitrotyrosine (3NTYR) produced by the reaction of nitrogen and oxygen species is used as a suitable marker of radical mediated tissue damage. Free or protein-bound tyrosin residues are in vivo nitrated most likely by peroxynitrite or myeloperoxidase. Processes involved in formation and degradation of 3NTYR are not completely clear. It seems that degradation depends on the way in which 3NTYR is formed, characteristics of the tissue or organ where 3NTYR was formed and even general condition of the organism. Nitration of tyrosine does not only modify the biochemical structure of the protein but usually affects its function. Nitrated proteins are probably specific for each organ and may influence the pathogenesis of the disease. The review also describes the methods of 3NTYR detection and summarizes published data on 3NTYR concentration in various human diseases.
