3-nitrotyrosin--indikátor zmĕn tvorby reaktivních sloucenin kyslíku a dusíku
[3-nitrotyrosine--an indicator of changes in the formation of reactive oxygen and nitrogen species]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
12608109
- MeSH
- Biomarkers analysis MeSH
- Humans MeSH
- Reactive Nitrogen Species biosynthesis MeSH
- Reactive Oxygen Species metabolism MeSH
- Tyrosine analogs & derivatives analysis MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- 3-nitrotyrosine MeSH Browser
- Biomarkers MeSH
- Reactive Nitrogen Species MeSH
- Reactive Oxygen Species MeSH
- Tyrosine MeSH
3-nitrotyrosine (3NTYR) produced by the reaction of nitrogen and oxygen species is used as a suitable marker of radical mediated tissue damage. Free or protein-bound tyrosin residues are in vivo nitrated most likely by peroxynitrite or myeloperoxidase. Processes involved in formation and degradation of 3NTYR are not completely clear. It seems that degradation depends on the way in which 3NTYR is formed, characteristics of the tissue or organ where 3NTYR was formed and even general condition of the organism. Nitration of tyrosine does not only modify the biochemical structure of the protein but usually affects its function. Nitrated proteins are probably specific for each organ and may influence the pathogenesis of the disease. The review also describes the methods of 3NTYR detection and summarizes published data on 3NTYR concentration in various human diseases.
