Analysis of Streptomyces ghanaensis ATCC14672 gene SSFG_07725 for putative γ-butyrolactone synthase
Language English Country United States Media print-electronic
Document type Journal Article
Grant support
BG-46F
Ministry of Education and Science of Ukraine
BG-41Nr
Ministry of Education and Science of Ukraine
PubMed
29786765
DOI
10.1007/s12223-018-0614-3
PII: 10.1007/s12223-018-0614-3
Knihovny.cz E-resources
- MeSH
- Bacterial Proteins genetics metabolism MeSH
- 4-Butyrolactone metabolism MeSH
- Mutation MeSH
- Oligosaccharides metabolism MeSH
- Streptomyces enzymology genetics MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Bacterial Proteins MeSH
- 4-Butyrolactone MeSH
- moenomycin MeSH Browser
- Oligosaccharides MeSH
Low molecular weight signaling compounds (LMWC) are important players in regulating various aspects of Streptomyces biology. Their exact roles in certain strain will ultimately depend on overall configuration of regulatory network and thus cannot be predicted on basis of in silico studies. Here, we explored S. ghanaensis gene SSFG_07725 (afsAgh) presumably involved in initial steps of formation of γ-butyrolactone LMWC. Disruption of afsAgh impaired aerial mycelium formation and increased the transcription of pleiotropic regulatory gene adpAgh, whereas level of moenomycin production remained virtually unaffected. We provide evidence that morphogenetic deficiency of afsAgh-minus mutant was caused by inability to produce diffusible LMWC. Possible links between γ-butyrolactone signaling and various aspects of S. ghanaensis biology are discussed.
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