Electrocardiographic dose-dependent changes in prophylactic doses of dosulepine, lithium and citalopram
Language English Country Czech Republic Media print
Document type Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't
PubMed
12790762
Knihovny.cz E-resources
- MeSH
- Analysis of Variance MeSH
- Antidepressive Agents, Second-Generation administration & dosage therapeutic use MeSH
- Antidepressive Agents, Tricyclic adverse effects therapeutic use MeSH
- Antidepressive Agents adverse effects therapeutic use MeSH
- Bipolar Disorder drug therapy MeSH
- Citalopram adverse effects therapeutic use MeSH
- Depressive Disorder drug therapy MeSH
- Adult MeSH
- Dothiepin adverse effects therapeutic use MeSH
- Electrocardiography drug effects MeSH
- Data Interpretation, Statistical MeSH
- Cardiovascular Physiological Phenomena drug effects MeSH
- Middle Aged MeSH
- Humans MeSH
- Lithium Carbonate adverse effects blood therapeutic use MeSH
- Body Surface Potential Mapping drug effects MeSH
- Statistics, Nonparametric MeSH
- Heart Rate drug effects MeSH
- Vectorcardiography drug effects MeSH
- Dose-Response Relationship, Drug MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Publication type
- Journal Article MeSH
- Controlled Clinical Trial MeSH
- Clinical Trial MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Antidepressive Agents, Second-Generation MeSH
- Antidepressive Agents, Tricyclic MeSH
- Antidepressive Agents MeSH
- Citalopram MeSH
- Dothiepin MeSH
- Lithium Carbonate MeSH
Tricyclic antidepressant drugs dosulepine (TCA), serotonin selective reuptake inhibitor (SSRI) and prophylactic agent with antidepressant effect lithium carbonicum (Li) have different cardiovascular side-effects. We compared them in the prophylactic therapy of periodic affective disorder in remission with TCA, SSRI and Li. Our previous papers confirmed the most prominent effects of heart electric field parameters in TCA patients (Slavícek et al., 1998). In the present work we studied for the first time the dose-dependent changes of ECG, body surface potential maps (BSPM - parameter DIAM 30, 40) in 43 TCA dosulepine, 40 SSRI citalopram and 30 Li outpatients (Hamilton scale: HAMDŁ10; age 40+/-5 years; treated for depressive disorders or bipolar disorders). The daily doses of dosulepine were 50-250 mg, citalopram 20-80 mg, Li plasma levels 0.66+/-0.08 meq/l. The electrocardiogram (ECG), vectorcardiogram (VCG), and BSPM were measured and calculated by the Cardiag 112.1 diagnostic system. The results have shown a relation between the dose of dosulepine and extremum (maximum and minimum) of depolarization isoarea map in dosulepine, but not in citalopram patients. The repolarization BSPM changes were most pronounced in SSRI patients. Lithium in long-term prophylaxy (1-22 years) caused only minimal ECG BSPM changes. The present results correspond with our previous observations.
