Congenitally determined neurodegeneration "Lurcher" induces morphofunctional changes of thymus
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
12879753
DOI
10.1007/bf02931373
Knihovny.cz E-zdroje
- MeSH
- apoptóza fyziologie MeSH
- degenerace nervu patologie MeSH
- ELISA MeSH
- myši - mutanty neurologické MeSH
- myši inbrední C3H MeSH
- myši MeSH
- nekróza MeSH
- průtoková cytometrie MeSH
- thymus patologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
A significantly higher frequency of apoptosis was documented by flow cytometry and by ELISA analysis, and significantly higher numbers of necrotic cells were demonstrated by ELISA within the thymus of Lurcher mice in comparison with the control C3H mice. These can be regarded as important markers of degenerative changes in this primary immune organ. This tendency is supported by histological observation of the absence of a clear interface between thymic cortex and medulla and an insignificantly increased number of Hassall's corpuscles resembling an onset of thymic atrophy.
Zobrazit více v PubMed
Nature. 1997 Aug 21;388(6644):769-73 PubMed
Eur Cytokine Netw. 1994 May-Jun;5(3):271-3 PubMed
Endocr Rev. 1996 Feb;17(1):64-102 PubMed
Eur J Immunol. 2000 Feb;30(2):337-46 PubMed
Immunol Today. 1994 Nov;15(11):518-23 PubMed
Neurobiol Learn Mem. 1996 Mar;65(2):113-20 PubMed
Brain Res Mol Brain Res. 1998 Nov 20;62(2):224-7 PubMed
Immunol Today. 1993 Sep;14(9):445-59 PubMed
Cell Tissue Res. 1974;151(3):347-68 PubMed
Science. 1987 Oct 23;238(4826):524-6 PubMed
J Neurosci. 1986 Jun;6(6):1733-7 PubMed
Annu Rev Physiol. 1986;48:475-94 PubMed
Neuroendocrinology. 1997 Nov;66(5):341-7 PubMed
Horm Metab Res. 1998 Jun-Jul;30(6-7):416-20 PubMed
Brain Res Dev Brain Res. 1995 May 26;86(1-2):311-6 PubMed
Philos Trans R Soc Lond B Biol Sci. 1979 Oct 11;287(1020):167-201 PubMed
Immunol Today. 1993 Apr;14(4):158-61 PubMed
Annu Rev Immunol. 1995;13:307-38 PubMed
Brain Res. 1976 Jul 30;111(2):396-8 PubMed
J Leukoc Biol. 1995 Aug;58(2):137-50 PubMed
N Engl J Med. 1995 May 18;332(20):1351-62 PubMed
Neurosci Res. 1995 Jul;22(4):423-6 PubMed
Science. 1987 Oct 23;238(4826):522-4 PubMed
Genome Res. 1995 Nov;5(4):381-92 PubMed
Res Immunol. 1992 Jan;143(1):129-39 PubMed
Int Arch Allergy Appl Immunol. 1969;35(1):97-104 PubMed
J Comp Neurol. 1977 May 1;173(1):205-18 PubMed
J Immunol. 1972 Mar;108(3):841-4 PubMed
Lurcher Mouse as a Model of Cerebellar Syndromes
Quantification of Solid Embryonic Cerebellar Graft Volume in a Degenerative Ataxia Model
