Congenitally determined neurodegeneration "Lurcher" induces morphofunctional changes of thymus
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
12879753
DOI
10.1007/bf02931373
Knihovny.cz E-resources
- MeSH
- Apoptosis physiology MeSH
- Nerve Degeneration pathology MeSH
- Enzyme-Linked Immunosorbent Assay MeSH
- Mice, Neurologic Mutants MeSH
- Mice, Inbred C3H MeSH
- Mice MeSH
- Necrosis MeSH
- Flow Cytometry MeSH
- Thymus Gland pathology MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
A significantly higher frequency of apoptosis was documented by flow cytometry and by ELISA analysis, and significantly higher numbers of necrotic cells were demonstrated by ELISA within the thymus of Lurcher mice in comparison with the control C3H mice. These can be regarded as important markers of degenerative changes in this primary immune organ. This tendency is supported by histological observation of the absence of a clear interface between thymic cortex and medulla and an insignificantly increased number of Hassall's corpuscles resembling an onset of thymic atrophy.
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