Antimycobacterial and antifungal isosters of salicylamides
Language English Country Germany Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Anti-Bacterial Agents chemical synthesis chemistry pharmacology MeSH
- Antifungal Agents chemical synthesis chemistry pharmacology MeSH
- Anti-Infective Agents chemical synthesis chemistry pharmacology MeSH
- Benzoates chemical synthesis chemistry pharmacology MeSH
- Benzoic Acid chemistry pharmacology MeSH
- Picolinic Acids chemical synthesis chemistry pharmacology MeSH
- Sulfanilic Acids chemical synthesis chemistry pharmacology MeSH
- Microbial Sensitivity Tests MeSH
- Drug Design MeSH
- Salicylanilides chemistry MeSH
- Salicylates MeSH
- Sulfhydryl Compounds MeSH
- Structure-Activity Relationship MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 3-hydroxypicolinic acid MeSH Browser
- Anti-Bacterial Agents MeSH
- Antifungal Agents MeSH
- Anti-Infective Agents MeSH
- Benzoates MeSH
- Benzoic Acid MeSH
- Picolinic Acids MeSH
- Sulfanilic Acids MeSH
- Salicylanilides MeSH
- Salicylates MeSH
- Sulfhydryl Compounds MeSH
- thiosalicylic acid MeSH Browser
A set of 40 derivatives of 3-hydroxypicolinic acid and 2-sulfanylbenzoic acid, isosteric to salicylanilides was synthesized. The compounds were evaluated for in vitro activity against Mycobacterium tuberculosis, Mycobacterium kansasii and Mycobacterium avium, Candida albicans, Candida tropicalis, Candida krusei, Candida glabrata, Trichosporon beigelii, Aspergillus fumigatus, Absidia corymbifera, Trichophyton mentagrophytes and Microsporum gypseum. Structure-activity relationships of antimycobacterial activity and antifungal activity against T. mentagrophytes and M. gypseum were analyzed by the Free-Wilson method. An increase in antimycobacterial activity was observed only for the sulfanylbenzoic acid derivatives, especially those with the benzyl moiety. The antifungal activity was not significant.
References provided by Crossref.org
Antifungal Activity of Salicylanilides and Their Esters with 4-(Trifluoromethyl)benzoic Acid
