Role of beta-catenin in the developing cortical and hippocampal neuroepithelium
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
14596855
DOI
10.1016/s0306-4522(03)00519-0
PII: S0306452203005190
Knihovny.cz E-zdroje
- MeSH
- beta-katenin MeSH
- cytoskeletální proteiny genetika metabolismus MeSH
- DNA vazebné proteiny metabolismus MeSH
- hipokampus embryologie růst a vývoj MeSH
- hybridizace in situ MeSH
- imunohistochemie MeSH
- mitóza MeSH
- mozková kůra embryologie růst a vývoj MeSH
- myši inbrední C57BL MeSH
- myši transgenní MeSH
- myši MeSH
- neuroglie metabolismus MeSH
- neurony metabolismus MeSH
- pohyb buněk * MeSH
- trans-aktivátory genetika metabolismus MeSH
- transkripční faktory genetika metabolismus MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- beta-katenin MeSH
- CTNNB1 protein, mouse MeSH Prohlížeč
- cytoskeletální proteiny MeSH
- DNA vazebné proteiny MeSH
- trans-aktivátory MeSH
- transkripční faktory MeSH
beta-Catenin plays a pivotal role in Wnt signaling during embryogenesis and is a component of adherens junctions. Since targeted disruption of the beta-catenin gene is lethal at gastrulation we have used a D6-Cre mouse line for conditional inactivation of beta-catenin in the mouse cerebral cortex and hippocampus after embryonic day (E) 10.5. In D6-Cre floxed beta-catenin mice, hippocampal CA1-CA2 fields are disrupted in similar manner as in Wnt-3a and LEF-1 mutants. The cortex of D6-Cre floxed beta-catenin mutants is strongly affected which contrasts with the normal cortex observed in Wnt-3a and LEF-1 mutants. Severe abnormalities in the organization of the neuroepithelium are observed that include disrupted interkinetic nuclear migration, loss of adherens junctions, impaired radial migration of neurons toward superficial layers and decreased cell proliferation after E15.5. At newborn stage, a premature disassembly of the radial glial scaffold and increased numbers of astrocytes are found in the cortex.
Citace poskytuje Crossref.org
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