Epidermolysis bullosa acquisita-like reaction associated with penicillamine therapy for sclerodermatous graft-versus-host disease
Language English Country United States Media print
Document type Case Reports, Journal Article
PubMed
14639407
DOI
10.1016/s0190-9622(03)00441-9
PII: S0190962203004419
Knihovny.cz E-resources
- MeSH
- Cyclosporine therapeutic use MeSH
- Epidermolysis Bullosa Acquisita chemically induced MeSH
- Immunosuppressive Agents therapeutic use MeSH
- Middle Aged MeSH
- Humans MeSH
- Methylprednisolone therapeutic use MeSH
- Graft vs Host Disease drug therapy MeSH
- Penicillamine adverse effects MeSH
- Scleroderma, Systemic drug therapy MeSH
- Bone Marrow Transplantation adverse effects MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Names of Substances
- Cyclosporine MeSH
- Immunosuppressive Agents MeSH
- Methylprednisolone MeSH
- Penicillamine MeSH
A case of a bullous eruption occurred in a patient being treated with penicillamine for sclerodermatous graft-versus-host disease following bone marrow transplantation. After 7 days of treatment with 150 mg penicillamine, a painful bullous eruption with accompanying purpuric lesions suddenly developed in previous sclerodermatous infiltrations. A diagnosis of epidermolysis bullosa acquisita-like eruption was made, and the patient was treated with drug withdrawal and administration of cyclosporine and methylprednisolone. Epidermolysis bullosa acquisita-like reaction is an extremely rare cutaneous side effect of penicillamine. The surprisingly early onset of this eruption in lesions of sclerodermatous graft-versus-host disease might have been due to severe immune alteration.
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