In vitro activities of 3-(halogenated phenyl)-5-acyloxymethyl- 2,5-dihydrofuran-2-ones against common and emerging yeasts and molds
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
14982778
PubMed Central
PMC353114
DOI
10.1128/aac.48.3.873-878.2004
Knihovny.cz E-resources
- MeSH
- Antifungal Agents pharmacology toxicity MeSH
- Fluconazole pharmacology MeSH
- Drug Resistance, Fungal MeSH
- Furans pharmacology toxicity MeSH
- Fungi drug effects ultrastructure MeSH
- Yeasts drug effects ultrastructure MeSH
- Lethal Dose 50 MeSH
- Leukemia L1210 drug therapy MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Mycoses microbiology MeSH
- Mice MeSH
- Antineoplastic Agents pharmacology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antifungal Agents MeSH
- Fluconazole MeSH
- Furans MeSH
- Antineoplastic Agents MeSH
Three 3-(halogenated phenyl)-5-acyloxymethyl-2,5-dihydrofuran-2-ones were evaluated for activity against 191 strains of common and emerging yeasts and Aspergillus species by the broth microdilution test performed according to NCCLS guidelines. The furanone derivatives displayed broad-spectrum in vitro activity against potentially pathogenic yeasts and molds, especially Aspergillus spp. (MIC
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