Annular elastolytic giant cell granuloma causes an irreversible disappearance of the elastic fibres
Language English Country England, Great Britain Media print
Document type Case Reports, Journal Article
PubMed
15096158
DOI
10.1111/j.1468-3083.2004.00912.x
PII: JDV912
Knihovny.cz E-resources
- MeSH
- Granuloma Annulare pathology MeSH
- Diagnosis, Differential MeSH
- Elastic Tissue pathology MeSH
- Phagocytosis MeSH
- Risk Assessment MeSH
- Immunohistochemistry MeSH
- Biopsy, Needle MeSH
- Humans MeSH
- Necrobiosis Lipoidica pathology MeSH
- Granuloma, Giant Cell pathology MeSH
- Prognosis MeSH
- Aged MeSH
- Severity of Illness Index MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
A 67-year-old man presented with grouped red papules with a smooth surface coalescing to relatively well-demarcated plaques on his left thigh, in the axillae and on the lateral parts of the trunk. The plaques were growing slowly, and the older ones had a frilled surface. A skin biopsy showed a zone of disappearance of the elastic fibres with a rim of giant multinuclear cells with fragments of the elastic fibres in their cytoplasm. This finding is typical of annular elastolytic giant cell granuloma (AEGCG). After corticosteroid therapy, the inflammation resolved, causing the frilled surface of the lesions due to the disappearance of the elastic fibres. Remission of the skin lesions lasted for 1.5 years. A second skin biopsy taken from the site of the previous lesion showed the absence of the elastic fibres, thus their phagocytosis was irreversible.
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