The normal histology of anogenital mammary-like glands (AGMLG) has been studied previously, but some aspects, including glandular depth, presence of columnar epithelium resembling columnar cell change/hyperplasia as defined in mammary pathology, and distribution of elastic fibers, have not been previously investigated. To address these issues, we studied 148 AGMLG identified in 133 paraffin blocks sampled from 64 vulvar wide excision or vulvectomy specimens (64 patients, various indications for surgery). The depth of AGMLG ranged from 0.64 to 3.9 mm. Epithelial columnar cell change was noted in 33.1% of all AGMLG, whereas columnar cell hyperplasia was detected in 10.1%. Occasionally, combinations of cuboidal epithelium and columnar cell change were seen within 1 histological section. Of 22 specimens stained for elastic fibers, in only 6 (27.3%) cases were elastic fibers found around glands. Periductal elastic fibers were demonstrated around 3 of the only 5 ducts, which were available for analysis in slides stained for elastic fibers. The depth of AGMLG should be taken into account when planning topical and surgical therapies for lesions derived or evolving from AGMLG. Alterations identical to columnar cell change may represent a normal variation of AGMLG.
- MeSH
- Anal Canal anatomy & histology MeSH
- Elastic Tissue cytology MeSH
- Epithelial Cells cytology MeSH
- Exocrine Glands anatomy & histology MeSH
- Humans MeSH
- Vulva anatomy & histology MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
Tunica adventitia or tunica externa is the outer layer of the blood vessel wall. It consists of connective tissue with vasa and nervi vasorum and plays a key role in vascular health. The aim of our study was to compare the wall layers beyond tunica media in arteries of different type and location. The following arteries of pig, dog and cat were processed histologically and analysed by light microscopy: aorta ascendens, arcus aortae, aorta thoracica, aorta abdominalis, arteria (a.) femoralis, a. tibialis cranialis, a. carotis communis, a. lingualis, a. basilaris, a. cerebralis media, a. testicularis and aa. jejunales. We found two layers of connective tissue outside the media: (1) a compact layer with many elastic fibres in muscular and few in elastic arteries and (2) an outer layer of loose connective tissue. The compact layer was missing in aorta ascendens, arcus aortae and intracranial vessels. Adventitial stripping removed only the loose connective tissue layer. In spite of the still present compact layer, stripped arteries were very flimsy. We suggest using the term 'tunica externa' for the compact connective tissue layer and 'tunica adventitia' for the outermost loose connective tissue layer as in other organs. The presence of the tunica externa differs between species, arteries and arterial side, as well as the removability of tunica adventitia and tunica externa by anatomical dissection.
- MeSH
- Adventitia anatomy & histology MeSH
- Aorta, Abdominal anatomy & histology MeSH
- Aorta, Thoracic anatomy & histology MeSH
- Elastic Tissue anatomy & histology MeSH
- Cats anatomy & histology MeSH
- Swine anatomy & histology MeSH
- Dogs anatomy & histology MeSH
- Muscle, Smooth, Vascular anatomy & histology MeSH
- Animals MeSH
- Check Tag
- Cats anatomy & histology MeSH
- Dogs anatomy & histology MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Keywords
- syndrom Buschke-Ollendorf,
- MeSH
- Diagnosis, Differential MeSH
- Child MeSH
- Elastic Tissue pathology MeSH
- Fibrosis MeSH
- Skin Diseases * diagnosis genetics MeSH
- Skin anatomy & histology pathology MeSH
- Humans MeSH
- Osteopoikilosis * diagnosis pathology MeSH
- Thigh abnormalities pathology MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
Idiopatická pleuropulmonální fibroelastóza (iPPFE) patří mezi vzácné idiopatické intersticiální pneumonie (IIP). Je charakterizována pleurální a v parenchymu subpleurální fibrózou a/nebo elastózou. Predominantně zprvu postihuje horní plicní laloky s následným postižením celé plíce. Etiologie a patofyziologie není zcela známá. Mezi typické znaky upozorňující na možnost iPPFE patří plochý hrudník (platythorax) a časem vznikající hyperkapnická respirační insuficience. Diagnóza bývá stanovena syntézou klinických, radiologických a histopatologických nálezů. Onemocnění má zpravidla progredující průběh. Konečným řešením pro pacienta je transplantace plic. Účinný lék bohužel není zatím k dispozici.
Idiopathic Pleuroparenchymal Fibroelastosis (iPPFE) is a rare idiopathic interstitial pneumonia (IIP). It is characterized by dense collagenous fibrosis and/or elastosis of the visceral pleura and subpleural tissue. iPPFE predominantly originates in the upper lung zones and later leads to progression to involve the entire lung. Etiology and pathophysiology still remains mystery for us. This disease has some typical signs which should be taken into consideration while thinking about possibility of having iPPFE. It is typically a flat chest (platythorax) and in time developing hypercapnic respiratory insufficiency. Diagnosis is build up on clinical, radiological and histopathological findings. Unfortunately, it is usually a progressive disease without knowing effective medication. Hence, lung transplantation is the only option for patient.
- Keywords
- idiopatická pleuropulmonální fibroelastóza, idiopatická pleuroparenchymatózní fibroelastóza, platythorax, hyperkapnická respirační insuficience, subpleurální fibróza, subpleurální elastóza, barvení na elastiku,
- MeSH
- Adult MeSH
- Elastic Tissue pathology MeSH
- Hypercapnia etiology MeSH
- Idiopathic Interstitial Pneumonias * diagnosis physiopathology radiography MeSH
- Humans MeSH
- Pleural Diseases * diagnosis physiopathology pathology MeSH
- Lung pathology MeSH
- Pulmonary Fibrosis * diagnosis etiology radiography MeSH
- Tomography, X-Ray Computed MeSH
- Disease Progression MeSH
- Radiography, Thoracic MeSH
- Respiratory Insufficiency etiology MeSH
- Spirometry MeSH
- Rare Diseases MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
The aim of the present study was to determine effect of two decellularized agents, sodium dodecyl sulphate (SDS) and Triton X-100, to the skeletal muscle tissue. Final scaffold was evaluated by several histological techniques to analyse preservation of essential structures including collagen and elastic fibres, basement membranes, glycosaminoglycans and also to confirm elimination of nuclear and cytoplasmic components which are redundant in effectively prepared decellularized scaffolds. Comparison of tissue scaffolds processed with different detergents proved that SDS is superior to Triton X-100 as it can effectively decellularize muscle tissue.
- MeSH
- Coloring Agents MeSH
- Sodium Dodecyl Sulfate pharmacology MeSH
- Elastic Tissue diagnostic imaging drug effects MeSH
- Glycosaminoglycans MeSH
- Collagen drug effects MeSH
- Muscle, Skeletal cytology drug effects MeSH
- Microscopy MeSH
- Mice MeSH
- Octoxynol pharmacology MeSH
- Surface-Active Agents pharmacology MeSH
- Tissue Scaffolds * MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- MeSH
- Biopsy MeSH
- Elastic Tissue * pathology MeSH
- Colonoscopy MeSH
- Middle Aged MeSH
- Humans MeSH
- Colonic Diseases diagnosis etiology pathology MeSH
- Colonic Polyps * diagnosis pathology therapy MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
- MeSH
- Biopsy MeSH
- Elastic Tissue * pathology MeSH
- Colonoscopy MeSH
- Middle Aged MeSH
- Humans MeSH
- Colonic Diseases diagnosis etiology pathology MeSH
- Colonic Polyps * diagnosis pathology therapy MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
Mid-dermální elastolýza (MDE) je vzácné kožní onemocnění nejasné etiologie, postihující především mladší ženy. V patogenezi se uvažuje o roli ultrafialového záření, histopatologicky charakterizované ztrátou elastických vláken ve střední úrovni dermis a klinicky se projevující okrsky jemně svraštělého povrchu kůže. Autoři popisují případ 34leté nemocné, která v minulosti navštěvovala solária, s dvouletou anamnézou kožních projevů histologicky potvrzené MDE postihující trup, zejména horní přední polovinu hrudníku. Po dvou letech sledování a aplikaci volně dostupných preparátů s obsahem sóji byl nález stacionární, bez progrese. Klíčová slova: mid-dermální elastolýza – svraštělá kůže
Mid-dermal elastolysis (MDE) is a rare skin disease of unknown etiology affecting epecially young women. The role of ultraviolet light is speculated in the pathogenesis of the disease which is histolopathologically characterised by the loss of elastic fibres in the middle dermis and clinically by the wrinked skin surface. Authors report a case of 34-year old women with history of tanning bed exposure presenting with skin lesions on the trunk especially the upper anterior part of the chest histopathologically verified as MDE. After 2 years of follow-up and local therapy with over the counter soya preparations the skin lesions remained stable. Key words: mid-dermal elastolysis – wrinkled skin
- MeSH
- Adult MeSH
- Elastic Tissue * pathology MeSH
- Skin Diseases diagnosis etiology therapy MeSH
- Humans MeSH
- Sunbathing MeSH
- Ultraviolet Rays * adverse effects MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
- Keywords
- aktinický granulom, obličejová necrobiosis lipoidica, Miescherův granulom obličeje, aktinické granuloma anulare, anulární elastolytický obrovskobuněčný granulom,
- MeSH
- Anti-Allergic Agents administration & dosage MeSH
- Anti-Inflammatory Agents administration & dosage MeSH
- Administration, Topical MeSH
- Administration, Oral MeSH
- Diabetes Mellitus, Type 2 complications MeSH
- Diagnosis, Differential MeSH
- Elastic Tissue pathology MeSH
- Hydroxychloroquine administration & dosage MeSH
- Enzyme Inhibitors administration & dosage MeSH
- Extremities MeSH
- Skin Diseases * diagnosis etiology drug therapy pathology MeSH
- Neck MeSH
- Middle Aged MeSH
- Humans MeSH
- Mometasone Furoate MeSH
- Granuloma, Giant Cell * diagnosis etiology drug therapy pathology MeSH
- Pregnadienediols administration & dosage MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
Papilární fi broelastom je vzácný primární nádor srdce, který se může stát zdrojem embolizací. V práci je popisován případ mladého asymptomatického muže s papilárním fi broelastomem aortální chlopně, který byl indikován k operačnímu řešení. Operací byl tumor zcela odstraněn při zachování aortální chlopně.
Papillary fi broelastoma of the aortic valve is a rare primary cardiac tumor which may potentially become a source of embolization. Our paper reports the case of a young asymptomatic man with papillary fi broelastoma of the aortic valve indicated for surgery. The procedure was successful in removing the tumor while sparing the aortic valve.
- Keywords
- Embolizace,
- MeSH
- Aortic Valve pathology MeSH
- Diagnosis, Differential MeSH
- Adult MeSH
- Echocardiography, Transesophageal MeSH
- Echocardiography MeSH
- Elastic Tissue pathology MeSH
- Embolism MeSH
- Fibroma MeSH
- Humans MeSH
- Heart Neoplasms diagnosis surgery physiopathology MeSH
- Risk MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Case Reports MeSH
