In vitro reactivation of tabun-inhibited acetylcholinesterase using new oximes--K027, K005, K033 and K048
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15141981
Knihovny.cz E-resources
- MeSH
- Cholinesterase Inhibitors toxicity MeSH
- Rats MeSH
- Brain enzymology MeSH
- Organophosphates toxicity MeSH
- Oximes chemical synthesis pharmacology toxicity MeSH
- Pyridinium Compounds chemical synthesis pharmacology toxicity MeSH
- Cholinesterase Reactivators chemical synthesis pharmacology MeSH
- In Vitro Techniques MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide MeSH Browser
- 1,3-bis(2-hydroxyiminomethylpyridinium)propane MeSH Browser
- 1,4-bis(2-hydroxyiminomethylpyridinium)butane MeSH Browser
- Cholinesterase Inhibitors MeSH
- Organophosphates MeSH
- Oximes MeSH
- Pyridinium Compounds MeSH
- Cholinesterase Reactivators MeSH
- tabun MeSH Browser
Four new AChE oximes for reactivation of acetylcholinesterase inhibited with tabun - K027 [1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium) propane dibromide], K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide], K033 [1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide] and K048 [1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide] were prepared. Their efficacies to reactivate tabun-inhibited acetylcholinesterase were studied and compared with the currently used acetylcholinesterase reactivators (pralidoxime, obidoxime and HI-6). Reactivator K048 seems to be promising reactivator of tabun-inhibited AChE. Its reactivation potency is significantly higher than the efficacy of HI-6 and pralidoxime, and comparable with the potency of the obidoxime at human relevant doses.
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