Gastric emptying of solids in children with H. pylori-positive and H. pylori-negative non-ulcer dyspepsia
Language English Country United States Media print
Document type Journal Article
PubMed
15319623
DOI
10.1097/00005176-200409000-00004
PII: 00005176-200409000-00004
Knihovny.cz E-resources
- MeSH
- Child MeSH
- Dyspepsia microbiology physiopathology MeSH
- Gastroscopy MeSH
- Helicobacter pylori * MeSH
- Helicobacter Infections microbiology physiopathology MeSH
- Humans MeSH
- Adolescent MeSH
- Prospective Studies MeSH
- Radionuclide Imaging methods MeSH
- Severity of Illness Index MeSH
- Gastric Emptying * MeSH
- Stomach diagnostic imaging microbiology pathology MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
OBJECTIVE: There is currently no data available in children on possible relationships among Helicobacter pylori, gastric motility and gastric inflammation. This is a prospective study of gastric emptying (GE) in symptomatic children with and without H. pylori who met symptom-based criteria for non-ulcer dyspepsia (NUD). METHODS: 47 consecutive dyspeptic patients (23 males; age range, 7 to 18 years) were enrolled. All patients had extensive negative diagnostic investigations. Scintigraphic solid-phase gastric emptying was assessed. RESULTS: 21 H. pylori-positive and 26 H. pylori-negative patients were identified with non-ulcer dyspepsia. The groups were not different in clinical symptoms except that pain related to feeding was more frequent in infected children (P < 0.03). Nodular antral gastritis was found more frequently in the H. pylori positive group (P < 0.0001). The gastritis score was more severe in H. pylori infected than H. pylori negative patients in both fundic and body mucosa (P < 0.001). Within the H. pylori-positive NUD group, the mean half-time GE of a solid meal was significantly accelerated compared to the non-infected group (P < 0.05). There was no difference in the intragastric food distribution and curves of gastric emptying of both groups. A significant relationship was found between the degree of gastric body inflammation gastric emptying, but not antral inflammation. Gastric emptying rate did not differ by sex or age of the subjects in either group. CONCLUSIONS: In dyspeptic children with H. pylori, gastric emptying of a solid was significantly accelerated compared with symptomatic H. pylori uninfected patients. This suggests that H. pylori is able to induce gastric emptying acceleration. Our findings add more information on H. pylori infection and gastroduodenal disease.
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