Genetic analysis of APOAV polymorphisms (T-1131/C, Ser19/Trp and Val153/Met): no effect on plasma remnant particles concentrations
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
15369751
DOI
10.1016/j.cccn.2004.05.011
PII: S0009898104002670
Knihovny.cz E-zdroje
- MeSH
- apolipoprotein A-V MeSH
- apolipoproteiny A MeSH
- apolipoproteiny genetika MeSH
- cholesterol krev MeSH
- dospělí MeSH
- frekvence genu MeSH
- genotyp MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- lipoproteiny krev MeSH
- polymerázová řetězová reakce MeSH
- polymorfismus genetický * MeSH
- triglyceridy krev MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- APOA5 protein, human MeSH Prohlížeč
- apolipoprotein A-V MeSH
- apolipoproteiny A MeSH
- apolipoproteiny MeSH
- cholesterol MeSH
- lipoproteiny MeSH
- remnant-like particle cholesterol MeSH Prohlížeč
- triglyceridy MeSH
BACKGROUND: APOAV is newly described protein, which plays a crucial role in the determination of plasma triglyceride (TG) levels. Remnant lipoproteins (RLPs) result from partial catabolised TG-rich particles. Elevated levels of RLP are associated with atherosclerosis, and they are a predictor of coronary events in patients with coronary artery disease. METHODS: We have evaluated the influence of APOAV polymorphisms (T-1131/C, Ser19/Trp and Val153/Met were measured by PCR and restriction analysis) on plasma levels of RLP-cholesterol and RLP-TG in 285 unrelated representative selected individuals (131 men and 154 women) aged 33-72 years. RESULTS: RLP-cholesterol and RLP-TG levels were not significantly influenced by the APOAV variants either in whole population or in males and females, if analyzed separately. CONCLUSIONS: We conclude that variations T-1131/C, Ser19/Trp and Val153/Met in the APOAV gene have no effect on plasma levels of remnant particles.
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