Probabilistic two-stage model of cell inactivation by ionizing particles
Language English Country Great Britain, England Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
15798334
DOI
10.1088/0031-9155/50/7/007
PII: S0031-9155(05)89037-2
Knihovny.cz E-resources
- MeSH
- Apoptosis radiation effects MeSH
- Models, Biological * MeSH
- Cell Line MeSH
- Cricetulus MeSH
- Radiation Dosage MeSH
- DNA radiation effects MeSH
- Fibroblasts physiology radiation effects MeSH
- Radiation, Ionizing * MeSH
- Cricetinae MeSH
- Computer Simulation MeSH
- DNA Damage * MeSH
- Models, Statistical MeSH
- Cell Survival radiation effects MeSH
- Dose-Response Relationship, Radiation MeSH
- Animals MeSH
- Check Tag
- Cricetinae MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- DNA MeSH
A model of biological effects of ionizing particles, especially of protons and other ions, is proposed. The model is based on distinguishing the single-particle and collective effects of the underlying radiobiological mechanism. The probabilities of individual particles causing severe damage to DNA, their synergetic or saturation combinations, and the effect of the cellular repair system are taken into account. The model enables one to describe linear, parabolic and more complex curves, including those exhibiting low-dose hypersensitivity phenomena, in a systematic way. Global shape as well as detailed structure of survival curves might be represented, which is crucial if different fractionation schemes in radiotherapy should be assessed precisely. Experimental cell-survival data for inactivation of V79 cells by low-energy protons have been analysed and corresponding detailed characteristics of the inactivation mechanism have been derived for this case.
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