Previous studies demonstrated that stimulant drugs, such as cocaine or amphetamine, administered during gestation or lactation may attenuate maternal behavior in rats. The effect of methamphetamine (MA), a drug whose usage has increased lately, on maternal behavior has not yet been investigated. The present study tested the effect of MA (5 mg/kg daily) administered prior to, during and after gestation on maternal behavior. Regularity of the estrous cycle, the incidence of impregnation, and the weight gain was compared between groups (control, saline- and MA-treated). Maternal behavior was examined using two tests: Observation test (without disturbance of the mother and pups) and Retrieval test (with short separation of pups from the mother). All tests were conducted prior to dosing each day. In the Observation test, MA decreased the blanket position of active nursing, while increasing passive nursing. There were no MA-induced changes in other maternal activities such as mother being in the nest, in contact with pups, or grooming pups. MA increased some non-maternal activities, such as drinking, eating, and sleeping, while decreasing stereotypic behavior (sniffing and rearing) when compared to controls. In the Retrieval test, MA-treated mothers were slower in retrieving the first pup, returning the first pup into the nest, and returning all pups into the nest. Interestingly, there were differences in maternal behavior also in saline-treated mothers relative to controls. Saline-treated mothers spent more time in the nest and groomed pups more than controls or MA-treated mothers. In conclusion, the present study demonstrates a novel finding that MA administered during pre-mating, gestational and lactational periods has a negative effect on maternal behavior toward pups.

Department of Normal Pathological and Clinical Physiology 3rd Faculty of Medicine Charles University Ke Karlovu 4 12000 Prague 2 Czech Republic

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