The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
15820528
DOI
10.1016/j.pbb.2005.01.012
PII: S0091-3057(05)00052-3
Knihovny.cz E-zdroje
- MeSH
- akustická stimulace MeSH
- antagonisté excitačních aminokyselin farmakologie MeSH
- antipsychotika farmakologie MeSH
- benzodiazepiny farmakologie MeSH
- dibenzothiepiny farmakologie MeSH
- dizocilpinmaleát antagonisté a inhibitory farmakologie MeSH
- klozapin farmakologie MeSH
- krysa rodu Rattus MeSH
- olanzapin MeSH
- potkani Wistar MeSH
- receptor serotoninový 5-HT2A účinky léků MeSH
- receptory dopaminu D2 agonisté MeSH
- receptory muskarinové účinky léků MeSH
- risperidon farmakologie MeSH
- úleková reakce účinky léků MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antagonisté excitačních aminokyselin MeSH
- antipsychotika MeSH
- benzodiazepiny MeSH
- dibenzothiepiny MeSH
- dizocilpinmaleát MeSH
- klozapin MeSH
- olanzapin MeSH
- receptor serotoninový 5-HT2A MeSH
- receptory dopaminu D2 MeSH
- receptory muskarinové MeSH
- risperidon MeSH
- zotepine MeSH Prohlížeč
Dizocilpine (MK-801; 0.3 mg/kg i.p.)-induced disruption in prepulse inhibition of the acoustic startle response (PPI) can be preferentially restored by "atypical" antipsychotics. In contrast, some findings indicate that not all of the "atypical" antipsychotics, such as clozapine and risperidone, are effective in restoring the NMDA antagonist-induced deficits in PPI. In our study, we evaluated the effect of four different "atypical" antipsychotic drugs on deficits in PPI induced by MK-801. Zotepine and risperidone have high affinities to D2-like and 5-HT2A receptors, while clozapine and olanzapine have multipharmacological profiles with the highest affinities to serotonin 5-HT1A,2A/2C receptors and muscarinic receptors. Results have shown that MK-801 disrupted PPI and increased the ASR in rats. Our results showed no effect of zotepine (1 and 2 mg/kg) and risperidone (0.1 and 1 mg/kg) on disrupted PPI by MK-801. Administration of clozapine (5 and 10 mg/kg) and olanzapine (2.5 and 5 mg/kg) restored the deficits in PPI induced by MK-801. Additionally, we found a decrease of approximately 46% in PPI after administration of clozapine (5 mg/kg) and olanzapine (2.5 and 5 mg/kg) without MK-801 treatment. In summary, the four "atypical" antipsychotics had different efficacies to restore the disrupted PPI by MK-801. Only clozapine and olanzapin restored the MK-801-induced deficits in PPI.
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