Heterocyclic isosters of antimycobacterial salicylanilides
Language English Country France Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
15910812
DOI
10.1016/j.farmac.2005.02.002
PII: S0014-827X(05)00060-1
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents chemical synthesis pharmacology MeSH
- Chemistry, Pharmaceutical methods MeSH
- Heterocyclic Compounds chemical synthesis pharmacology MeSH
- Microbial Sensitivity Tests methods MeSH
- Salicylamides chemical synthesis pharmacology MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Heterocyclic Compounds MeSH
- Salicylamides MeSH
A series of 64 derivatives of substituted heterocyclic analogues of salicylanilides was synthesized. The compounds were evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacterium kansasii. For the QSAR study, the combination of Free-Wilson approach with Hansch approach was used. The molecules were separated on the heterocyclic and salicyl moieties and the study of influences of electronic and hydrophobic properties was used as well. The compounds are a new group of potential anti-tuberculotics.
References provided by Crossref.org
Design, Synthesis and Evaluation of N-pyrazinylbenzamides as Potential Antimycobacterial Agents
