Heterocyclic isosters of antimycobacterial salicylanilides

. 2005 May ; 60 (5) : 399-408. [epub] 20050412

Jazyk angličtina Země Francie Médium print-electronic

Typ dokumentu časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/pmid15910812
Odkazy

PubMed 15910812
DOI 10.1016/j.farmac.2005.02.002
PII: S0014-827X(05)00060-1
Knihovny.cz E-zdroje

A series of 64 derivatives of substituted heterocyclic analogues of salicylanilides was synthesized. The compounds were evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacterium kansasii. For the QSAR study, the combination of Free-Wilson approach with Hansch approach was used. The molecules were separated on the heterocyclic and salicyl moieties and the study of influences of electronic and hydrophobic properties was used as well. The compounds are a new group of potential anti-tuberculotics.

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