Anticonvulsant action of an antagonist of metabotropic glutamate receptors mGluR5 MPEP in immature rats
Language English Country Great Britain, England Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
15950993
DOI
10.1016/j.neuropharm.2005.04.020
PII: S0028-3908(05)00170-X
Knihovny.cz E-resources
- MeSH
- Epilepsy, Absence chemically induced drug therapy MeSH
- Analysis of Variance MeSH
- Anticonvulsants therapeutic use MeSH
- Electric Stimulation adverse effects MeSH
- Electroencephalography methods MeSH
- Epilepsy drug therapy etiology MeSH
- Rats MeSH
- Receptor, Metabotropic Glutamate 5 MeSH
- Disease Models, Animal MeSH
- Cerebral Cortex drug effects physiopathology radiation effects MeSH
- Animals, Newborn MeSH
- Rats, Wistar MeSH
- Pyridines therapeutic use MeSH
- Reaction Time drug effects physiology radiation effects MeSH
- Receptors, Metabotropic Glutamate antagonists & inhibitors MeSH
- Age Factors MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- 6-methyl-2-(phenylethynyl)pyridine MeSH Browser
- Anticonvulsants MeSH
- Grm5 protein, rat MeSH Browser
- Receptor, Metabotropic Glutamate 5 MeSH
- Pyridines MeSH
- Receptors, Metabotropic Glutamate MeSH
Antagonists of type I of metabotropic glutamate receptors exhibit anticonvulsant action in adult as well as immature rodents. To know the anticonvulsant profile of a specific mGluR5 antagonist MPEP in developing rats, two models of epileptic seizures were used. MPEP (10, 20 or 40 mg/kg i.p.) suppressed in a dose-dependent manner epileptic afterdischarges induced by electrical stimulation of sensorimotor cortical area in three age groups (12, 18 and 25 days old). The anticonvulsant action was more expressed in the youngest group than in older animals so that in 25-day-old rats an additional dose of 80 mg/kg was used. In contrast to this marked anticonvulsant action, MPEP at a dose of 40 mg/kg i.p. in 18-day-old rat pups and at doses of 40 and 80 mg/kg in 25-day-old rat pups did not affect episodes of spike-and-wave rhythm elicited by low doses of pentetrazol. Our results delineate the profile of the anticonvulsant action of MPEP and confirm the higher efficacy of this antagonist at early developmental stages in comparison with prepubertal animals.
References provided by Crossref.org
Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
