Generation of landomycin D-producing strain Streptomyces globisporus LD3
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15954529
DOI
10.1007/bf02931289
Knihovny.cz E-resources
- MeSH
- Aminoglycosides biosynthesis genetics pharmacology MeSH
- Anti-Bacterial Agents biosynthesis pharmacology MeSH
- Genes, Bacterial MeSH
- Drug Resistance, Bacterial MeSH
- Gene Deletion MeSH
- Glycosylation MeSH
- Streptomyces genetics metabolism MeSH
- Genetic Complementation Test MeSH
- Transferases genetics MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Aminoglycosides MeSH
- Anti-Bacterial Agents MeSH
- landomycin D MeSH Browser
- landomycin E MeSH Browser
- Transferases MeSH
Rhodinosyl transferase gene lndGT4, governing the conversion of the disaccharide oligoketide ('polyketide') landomycin D into a trisaccharide derivative landomycin E, was deleted in Streptomyces globisporus 1912 genome. Possible resistance mechanisms that protect the resulting landomycin D-producing mutant strain S. globisporus LD3 against the toxic action of landomycins were determined.
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