Cytoprotectivity of Prunella vulgaris on doxorubicin-treated rat cardiomyocytes
Language English Country Netherlands Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15972250
DOI
10.1016/j.fitote.2005.04.019
PII: S0367-326X(05)00112-7
Knihovny.cz E-resources
- MeSH
- Cinnamates administration & dosage pharmacology therapeutic use MeSH
- Depsides MeSH
- Doxorubicin MeSH
- Phytotherapy * MeSH
- Myocytes, Cardiac drug effects MeSH
- Cardiotonic Agents administration & dosage pharmacology therapeutic use MeSH
- Rats MeSH
- Rosmarinic Acid MeSH
- Oxidative Stress * MeSH
- Rats, Sprague-Dawley MeSH
- Antibiotics, Antineoplastic MeSH
- Prunella * MeSH
- Plant Extracts administration & dosage pharmacology therapeutic use MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cinnamates MeSH
- Depsides MeSH
- Doxorubicin MeSH
- Cardiotonic Agents MeSH
- Antibiotics, Antineoplastic MeSH
- Plant Extracts MeSH
The cardioprotective effect of Prunella vulgaris ethylacetate fraction (PVEF) and its constituent rosmarinic acid (RA) was evaluated on isolated rat cardiomyocytes subjected to doxorubicin-induced oxidative stress. The cytoprotectivities of PVEF and RA were concentration-dependent in the range of 0.005 to 0.05 mg/ml and the effect of PVEF correlated with the RA content. Dexrazoxan (DE), used as positive control, was less effective than PVEF or RA.
References provided by Crossref.org
