Endoplasmic Reticulum-Associated Degradation [degradace proteinů v endoplasmatickém retikulu]

topical
3
Terms

degradace defektních proteinů v endoplasmatickém retikulu
degradace spojená s endoplazmatickým retikulem
degradační dráha asociovaná s endoplasmatickým retikulem
dráha ERAD
ERAD dráha
proces ERAD

 

ERAD Pathway

Persistent link   https://www.medvik.cz/link/D060746
Definition

A degradation process whereby incorrectly folded proteins are selectively transported out of the ENDOPLASMIC RETICULUM and into the CYTOSOL. The misfolded proteins are subsequently ubiquitinated and degraded by the PROTEASOME.

DUI
D060746 MeSH Browser
CUI
M0555322
Previous indexing
Protein Folding (1995-2011)
History note
2012
Public note
2012

Allowable subheadings

DE
drug effects
GE
genetics
IM
immunology
PH
physiology
RE
radiation effects

G Phenomena and Processes
G02 Chemical Phenomena 308
G02.111 Biochemical Phenomena 370
G02.111.660 Peptide Biosynthesis 43
G02.111.660.871 Protein Biosynthesis 426
G02.111.660.871.790 Protein Modification, Translational 7
G02.111.660.871.790.600 Protein Processing, Post-Translational 200
G02.111.660.871.790.600.962 Unfolded Protein Response 21
G02.111.660.871.790.600.962.500 Endoplasmic Reticulum-Associated Degradation 3
G02.111.691 Protein Modification, Translational 7
G02.111.691.600 Protein Processing, Post-Translational 200
G02.111.691.600.850 Unfolded Protein Response 21
G02.111.691.600.850.500 Endoplasmic Reticulum-Associated Degradation 3
G03 Metabolism 1 199
G03 Metabolic Phenomena obsolete
G03.734 Peptide Biosynthesis 43
G03.734.871 Protein Biosynthesis 426
G03.734.871.790 Protein Modification, Translational 7
G03.734.871.790.600 Protein Processing, Post-Translational 200
G03.734.871.790.600.850 Unfolded Protein Response 21
G03.734.871.790.600.850.500 Endoplasmic Reticulum-Associated Degradation 3
G04 Cell Physiological Phenomena 515
G04.434 Endoplasmic Reticulum Stress 54
G04.434.500 Unfolded Protein Response 21
G04.434.500.500 Endoplasmic Reticulum-Associated Degradation 3
G05 Genetic Phenomena 135
G05.308 Gene Expression Regulation 1 080
G05.308.670 Protein Modification, Translational 7
G05.308.670.600 Protein Processing, Post-Translational 200
G05.308.670.600.850 Unfolded Protein Response 21
G05.308.670.600.850.500 Endoplasmic Reticulum-Associated Degradation 3

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