Thermoresponsive polymers as promising new materials for local radiotherapy
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15996473
DOI
10.1016/j.apradiso.2005.05.043
PII: S0969-8043(05)00152-1
Knihovny.cz E-resources
- MeSH
- Acrylic Resins chemistry MeSH
- Calorimetry, Differential Scanning MeSH
- Pentetic Acid chemistry MeSH
- Radiotherapy instrumentation MeSH
- Body Temperature MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Acrylic Resins MeSH
- Pentetic Acid MeSH
- poly-N-isopropylacrylamide MeSH Browser
We describe a novel thermoresponsive polymeric drug delivery system based on poly(N-isopropylacrylamide) with isotopically labellable end groups [l-tyrosinamide or diethylenetriaminepentaacetic acid (DTPA)] designed for local radiotherapy. The polymers are readily soluble in isotonic aqueous sodium chloride at room temperature and the phase separation is complete at body temperature as proved by DSC measurements. Sufficent binding capacity for radionuclides and chemical stability are demonstrated on 125I and 90Y-labelled polymers.
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