Hepcidin: a direct link between iron metabolism and immunity
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
16009323
DOI
10.1016/j.biocel.2005.02.023
PII: S1357-2725(05)00079-8
Knihovny.cz E-zdroje
- MeSH
- buněčná imunita * MeSH
- hepcidiny MeSH
- kationické antimikrobiální peptidy fyziologie MeSH
- lidé MeSH
- mediátory zánětu fyziologie MeSH
- molekulární sekvence - údaje MeSH
- poruchy metabolismu železa etiologie MeSH
- sekvence aminokyselin MeSH
- zánět komplikace MeSH
- železo metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- HAMP protein, human MeSH Prohlížeč
- hepcidiny MeSH
- kationické antimikrobiální peptidy MeSH
- mediátory zánětu MeSH
- železo MeSH
Hepcidin, originally discovered in urine as a bactericidal peptide synthesized by hepatocytes was later proved to be a key regulator of iron metabolism at the whole body level, namely, in conditions of altered iron demand such as the increased or decreased total amount of body iron, inflammation, hypoxia and anemia. The major mechanism of hepcidin function seems to be the regulation of transmembrane iron transport. Hepcidin binds to its receptor, protein ferroportin, which serves as a transmembrane iron channel enabling iron efflux from cells. The hepcidin-ferroportin complex is then degraded in lysosomes and iron is locked inside the cells (mainly enterocytes, hepatocytes and macrophages). This leads to lowering of iron absorption in the intestine and to a decrease in serum iron concentration. Utilizing this mechanism, hepcidin regulates serum iron levels during inflammation, infection and possibly also in cancer. Under these conditions iron is shifted from circulation into cellular stores in hepatocytes and macrophages, making it less available for invading microorganisms and tumor cells. In anemia and hypoxia, hepcidin regulates the availability of iron for erythropoiesis. Hepcidin or hepcidin-related therapeutics could find a place in the treatment of various diseases such as hemochromatosis and anemia of chronic disease.
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