Antibiotic-induced release of inflammatory mediators from bacteria in experimental Klebsiella pneumoniae-induced sepsis
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
16110923
DOI
10.1007/bf02931467
Knihovny.cz E-zdroje
- MeSH
- amikacin farmakologie terapeutické užití MeSH
- antibakteriální látky farmakologie terapeutické užití MeSH
- ceftazidim farmakologie terapeutické užití MeSH
- endotoxiny metabolismus MeSH
- infekce bakteriemi rodu Klebsiella komplikace farmakoterapie mikrobiologie MeSH
- Klebsiella pneumoniae účinky léků patogenita MeSH
- lidé MeSH
- modely nemocí na zvířatech MeSH
- myši MeSH
- ofloxacin farmakologie terapeutické užití MeSH
- sepse farmakoterapie mikrobiologie mortalita MeSH
- TNF-alfa metabolismus MeSH
- zánět MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- amikacin MeSH
- antibakteriální látky MeSH
- ceftazidim MeSH
- endotoxiny MeSH
- ofloxacin MeSH
- TNF-alfa MeSH
In a fibrin-clot model of sepsis, developed in mice, treatment with the antibiotics ceftazidime (Cfz) and ofloxacin (Ofl) caused significant (p < 0.01) release of endotoxin and TNF-alpha after 4.5 h when compared with control (untreated) and amikacin (Ami) treated group. Except for control group, the level of bacteremia declined in all three antibiotic-treated groups. The results suggest that antibiotic therapy, irrespective of the agent used, results in an increase in endotoxin levels in vivo. The amount of endotoxin liberated by Ami was much smaller than with Cfz and Ofl therapy, which makes it an appropriate agent for the treatment of sepsis. An increase in the level of TNF-alpha along with endotoxin is suggestive of increased inflammatory response.
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J Toxicol Environ Health. 1997 Aug 8;51(5):415-35 PubMed
J Endotoxin Res. 2003;9(6):349-60 PubMed
Folia Microbiol (Praha). 2003;48(5):699-702 PubMed
J Infect Dis. 1990 Apr;161(4):721-7 PubMed
J Immunol. 1988 Aug 1;141(3):870-4 PubMed
J Clin Microbiol. 1976 Jan;3(1):21-5 PubMed
Am J Med. 1980 Mar;68(3):344-55 PubMed
J Antimicrob Chemother. 1992 Aug;30(2):165-72 PubMed
FASEB J. 1991 Sep;5(12):2652-60 PubMed
Folia Microbiol (Praha). 2004;49(6):737-44 PubMed
J Med Microbiol. 1994 Jan;40(1):23-30 PubMed
N Engl J Med. 1993 May 20;328(20):1471-7 PubMed
Science. 2002 Apr 12;296(5566):298-300 PubMed
Antimicrob Agents Chemother. 2004 Jan;48(1):93-9 PubMed
Antimicrob Agents Chemother. 1994 Jun;38(6):1211-8 PubMed
Antimicrob Agents Chemother. 1991 Nov;35(11):2388-94 PubMed
Folia Microbiol (Praha). 2003;48(5):665-9 PubMed
J Infect Dis. 1992 Jun;165(6):1033-41 PubMed
Crit Care Med. 1997 Aug;25(8):1270-1 PubMed
J Infect Dis. 1991 Oct;164(4):800-2 PubMed
J Infect Dis. 1996 Jan;173(1):203-11 PubMed
Infect Immun. 2000 Apr;68(4):2301-8 PubMed
Clin Microbiol Rev. 2000 Oct;13(4):615-50 PubMed
J Antimicrob Chemother. 1998 Apr;41(4):435-42 PubMed
Antimicrob Agents Chemother. 1999 May;43(5):1003-12 PubMed
J Med Microbiol. 1999 Mar;48(3):309-315 PubMed
