Analysis of recombinant group B streptococcal protein ScaAB and evaluation of its immunogenicity
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16110924
DOI
10.1007/bf02931468
Knihovny.cz E-resources
- MeSH
- Bacterial Adhesion MeSH
- Bacterial Proteins chemistry genetics immunology metabolism MeSH
- Immunization MeSH
- Membrane Proteins chemistry genetics immunology metabolism MeSH
- Molecular Sequence Data MeSH
- Mice MeSH
- Antibodies, Bacterial blood MeSH
- Recombinant Proteins chemistry genetics immunology metabolism MeSH
- Amino Acid Sequence MeSH
- Streptococcus agalactiae immunology isolation & purification pathogenicity MeSH
- Streptococcal Infections microbiology mortality prevention & control MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Bacterial Proteins MeSH
- Membrane Proteins MeSH
- Antibodies, Bacterial MeSH
- Recombinant Proteins MeSH
Group B streptococcal (GBS) gene encoding the putative lipoprotein and adherence factor ScaAB was cloned and expressed in E. coli. Recombinant ScaAB protein was isolated. Signal sequence of ScaAB was found to be cleaved in the E. coli host. ScaAB recombinant protein was immunogenic in mice and antibodies against this protein were discovered in mice sera after GBS infection. The perspectives of the use of ScaAB protein in GBS vaccine are discussed.
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