Development of ciprofloxacin resistance due to chromosomal mutations induced by 2-nitrofluorene
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.
2005 Dec ;
149 (2) :
401-3.
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
Persistent link
https://www.medvik.cz/link/pmid16601798
PubMed
16601798
Knihovny.cz E-resources
- MeSH
- Anti-Infective Agents pharmacology MeSH
- Genes, Bacterial drug effects MeSH
- Drug Resistance, Bacterial genetics MeSH
- Ciprofloxacin pharmacology MeSH
- Fluorenes pharmacology MeSH
- Mutation drug effects MeSH
- Salmonella typhimurium drug effects genetics MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 2-nitrofluorene MeSH Browser
- Anti-Infective Agents MeSH
- Ciprofloxacin MeSH
- Fluorenes MeSH
In this paper we investigated the ability of 2-nitrofluorene to induce mutations leading to antibiotic resistance in quinolone-sensitive strain Salmonella typhimurium. After preincubation of bacteria with 2-nitrofluorene, the frequency of mutation to ciprofloxacin resistance was 57 fold higher than in the case of spontaneous mutability. Some of resultant resistant colonies showed a great increase of ciprofloxacin MIC.
