Cytotoxicity and aryl hydrocarbon receptor-mediated activity of n-heterocyclic polycyclic aromatic hydrocarbons: structure-activity relationships
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
16704060
DOI
10.1897/05-388r.1
Knihovny.cz E-zdroje
- MeSH
- biotest MeSH
- heterocyklické sloučeniny chemie toxicita MeSH
- hydrofobní a hydrofilní interakce MeSH
- krysa rodu Rattus MeSH
- kvantitativní vztahy mezi strukturou a aktivitou MeSH
- molekulární struktura MeSH
- nádorové buněčné linie MeSH
- polycyklické aromatické uhlovodíky chemie toxicita MeSH
- receptory aromatických uhlovodíků genetika metabolismus MeSH
- regulace genové exprese účinky léků MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- heterocyklické sloučeniny MeSH
- polycyklické aromatické uhlovodíky MeSH
- receptory aromatických uhlovodíků MeSH
Toxic effects of many persistent organic pollutants (e.g., polychlorinated biphenyls or polychlorinated dibenzo-p-dioxins and furans) are mediated via the aryl hydrocarbon receptor (AhR). Although polycyclic aromatic hydrocarbons (PAHs) and their derivatives also activate AhR, their toxic effects remain to be fully elucidated. In the present study, we used the in vitro H4IIE-luc transactivation cell assay to investigate cytotoxicity and potencies to activate AhR by 29 individual PAHs and their N-heterocyclic derivatives (aza-PAHs). The aza-PAHs were found to be significantly more cytotoxic and more potent inducers of AhR than their unsubstituted analogues. Several aza-PAHs, such as dibenz[a,h]acridine or dibenz[a,i]acridine, activated AhR within picomolar concentrations, comparable to the effects of reference 2,3,7,8-tetrachlorodibenzo-p-dioxin. Ellipsoidal volume, molar refractivity, and molecular size were the most important descriptors derived from the modeling of quantitative structure-activity relationships for potencies to activate AhR. Comparable relative toxic potencies (induction equivalency factors) for individual aza-PAHs are derived, and their use for evaluation of complex contaminated samples is discussed.
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