Teratoma in an adolescent with malignant transformation into embryonal rhabdomyosarcoma: case report
Language English Country United States Media print
Document type Case Reports, Journal Article, Research Support, Non-U.S. Gov't
PubMed
17023832
DOI
10.1097/01.mph.0000212992.72059.eb
PII: 00043426-200610000-00011
Knihovny.cz E-resources
- MeSH
- Chromosome Aberrations MeSH
- Cytogenetic Analysis MeSH
- Rhabdomyosarcoma, Embryonal diagnosis genetics therapy MeSH
- Fatal Outcome MeSH
- Immunohistochemistry MeSH
- Humans MeSH
- Chromosomes, Human, Pair 12 genetics MeSH
- Lymphatic Metastasis MeSH
- Adolescent MeSH
- Cell Transformation, Neoplastic genetics MeSH
- Mediastinal Neoplasms diagnosis genetics therapy MeSH
- Lung Neoplasms diagnosis secondary MeSH
- Neoplasm, Residual MeSH
- Neoplasms, Second Primary diagnosis genetics therapy MeSH
- Teratoma diagnosis genetics therapy MeSH
- Check Tag
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
BACKGROUND: The somatic type tumors are occasionally found in nonseminomatous germ cell tumors in men. These malignancies are presumed to arise from malignant transformation (MT) of teratoma or by differentiation of totipotential germ cell. OBSERVATION: A case of MT of germ cell tumor in 17-year-old male into embryonal rhabdomyosarcoma is described. The histopathologic diagnosis was that of embryonal rhabdomyosarcoma in which no germ cell elements were found. The germ cell origin of transformed histology is supported by cytogenetic analysis (isochromosome 12p), and elevated alpha(1)-fetoprotein. Despite intensive therapy the patient died. CONCLUSIONS: MT of teratoma is rare entity with poor prognosis.
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