Cytokine gene polymorphisms and high-resolution-computed tomography score in idiopathic pulmonary fibrosis
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
17056243
DOI
10.1016/j.rmed.2006.09.013
PII: S0954-6111(06)00453-7
Knihovny.cz E-resources
- MeSH
- Interleukin 1 Receptor Antagonist Protein genetics MeSH
- Adult MeSH
- Phenotype MeSH
- Genetic Predisposition to Disease MeSH
- Genotype MeSH
- Interleukin-12 genetics MeSH
- Interleukin-4 genetics MeSH
- Interleukins genetics MeSH
- Middle Aged MeSH
- Humans MeSH
- Pulmonary Alveoli diagnostic imaging MeSH
- Pulmonary Fibrosis diagnostic imaging genetics MeSH
- Tomography, X-Ray Computed MeSH
- Polymorphism, Genetic * MeSH
- Disease Progression MeSH
- Interleukin-4 Receptor alpha Subunit genetics MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Severity of Illness Index MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Interleukin 1 Receptor Antagonist Protein MeSH
- IL1RN protein, human MeSH Browser
- Interleukin-12 MeSH
- Interleukin-4 MeSH
- Interleukins MeSH
- Interleukin-4 Receptor alpha Subunit MeSH
INTRODUCTION: Idiopathic pulmonary fibrosis (IPF) is a serious disease with unknown cause and the influence of cytokine gene polymorphisms is presumed in the etiology and pathogenesis of the disease. We used high-resolution computed tomography (HRCT) as a marker of disease stage and progression and compared the alveolar and interstitial score with IL-1, IL-4, IL-12, IL-1RA and IL-4RA cytokine gene polymorphisms. SUBJECTS AND METHODS: The IPF patients were all Caucasians from the Czech Republic and consisted of 20 females and 10 males, with a mean age of 65 years, range 36-85. The HRCT results were evaluated by an experienced viewer using the interstitial and alveolar score scales, which were based on the IPF HRCT description system from Gay SE, Kazerooni EA, Tows GB, Lynch JP, Gross BH, Cascade PN, et al. [Idiopathic pulmonary fibrosis. Predicting response to therapy and survival. Am J Respir Crit Care Med 1998;157:1063-72]. We evaluated the polymorphisms of cytokine genes utilizing a PCR with sequence-specific primers method. RESULTS: The HRCT alveolar score was more pronounced in IL-4 RA (+1902) AG heterozygotes. The HRCT interstitial score was less severe in the IL-12 (-1188) AA homozygotes. According to progression of the HRCT interstitial score, the CC homozygosity at IL-1 RA (mspa 111100), the AA homozygosity at IL-4 RA (+1902) and CC homozygosity at IL-4(+33) positions were more frequent in patients with stable disease compared to those with progressive disease. CONCLUSIONS: We assume from our data that the polymorphisms of IL-4, IL-4RA, IL-1RA and IL-12 genes (genes of cytokines with regulatory activity) might influence the phenotype of IPF as shown by measurable changes in HRCT investigations.
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