Quo vadis porphyrin chemistry?
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
- MeSH
- Models, Biological MeSH
- Photochemotherapy * MeSH
- Heme metabolism MeSH
- Carbon Monoxide metabolism MeSH
- Porphyrins chemistry therapeutic use MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Heme MeSH
- Carbon Monoxide MeSH
- Porphyrins MeSH
This review summarizes recent developments in the area of porphyrin chemistry in the direction of biological applications. Novel synthetic methodologies are reviewed for porphyrin synthesis, porphyrin analog synthesis, stable porphyrinogens -- calixpyrroles, expanded porphyrins. Unique biological properties of those compounds are desribed with focus on photodynamic therapy (PDT) and molecular recognition properties. Special attentions given to metalloporphyrins with potential to affect heme degradation and CO formation.
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