Adenosine A(3) receptor agonist acts as a homeostatic regulator of bone marrow hematopoiesis
Language English Country France Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
17383145
DOI
10.1016/j.biopha.2007.02.010
PII: S0753-3322(07)00024-8
Knihovny.cz E-resources
- MeSH
- Adenosine analogs & derivatives pharmacology MeSH
- Adenosine A3 Receptor Agonists * MeSH
- Cell Lineage MeSH
- Bone Marrow Cells drug effects MeSH
- Erythroid Cells drug effects MeSH
- Granulocytes drug effects MeSH
- Hematopoiesis drug effects MeSH
- Homeostasis drug effects MeSH
- Mice, Inbred Strains MeSH
- Bone Marrow physiology MeSH
- Mice MeSH
- Cell Proliferation drug effects MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adenosine MeSH
- Adenosine A3 Receptor Agonists * MeSH
- N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine MeSH Browser
The present study was performed to define the optimum conditions of the stimulatory action of the adenosine A(3) receptor agonist, N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA), on bone marrow hematopoiesis in mice. Effects of 2-day treatment with IB-MECA given at single doses of 200nmol/kg twice daily were investigated in normal mice and in mice whose femoral bone marrow cells were either depleted or regenerating after pretreatment with the cytotoxic drug 5-fluorouracil. Morphological criteria were used to determine the proliferation state of the granulocytic and erythroid cell systems. Significant negative correlation between the control proliferation state and the increase of cell proliferation after IB-MECA treatment irrespective of the cell lineage investigated was found. The results suggest the homeostatic character of the induced stimulatory effects and the need to respect the functional state of the target tissue when investigating effects of adenosine receptor agonists under in vivo conditions.
References provided by Crossref.org
The role of adenosine receptor agonists in regulation of hematopoiesis
