Increased intima-media thickness of the common carotid artery in primary aldosteronism in comparison with essential hypertension
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
17563568
DOI
10.1097/hjh.0b013e3281268532
PII: 00004872-200707000-00022
Knihovny.cz E-zdroje
- MeSH
- arteria carotis communis diagnostické zobrazování patologie MeSH
- dopplerovská echokardiografie MeSH
- dospělí MeSH
- hyperaldosteronismus diagnostické zobrazování patologie MeSH
- hypertenze diagnostické zobrazování patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- tunica intima diagnostické zobrazování patologie MeSH
- tunica media diagnostické zobrazování patologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
BACKGROUND: Aldosterone contributes to the accumulation of collagen fibers and extracellular matrix in arterial wall. The aim of this study was to compare intima-media thickness (IMT) of the common carotid artery and carotid bifurcation in patients with primary aldosteronism, essential hypertension and healthy controls. METHODS: Carotid ultrasound studies were carried out in 33 patients aged 42-72 years with primary aldosteronism, 52 patients with essential hypertension and in 33 normotensive controls. RESULTS: The patients with primary aldosteronism had significantly higher IMT of the common carotid artery than patients with essential hypertension and controls (0.987 +/- 0.152 mm; 0.892 +/- 0.154 mm versus 0.812 +/- 0.124 mm; P < 0.001; P < 0.05). There was also significantly higher IMT of the common carotid in patients with essential hypertension compared to control group (0.892 +/- 0.154 mm versus 0.812 +/- 0.124 mm; P < 0.01). The differences between both hypertensive groups remained statistically significant after adjustment for age and 24-h systolic blood pressure (P = 0.001). The differences of the IMT in the carotid bifurcation were statistically significant only between patients with primary aldosteronism and controls (1.157 +/- 0.243 mm versus 0.994 +/- 0.199 mm; P <0.05). CONCLUSION: Patients with primary aldosteronism have increased common carotid IMT compared to the patients with essential hypertension. This finding could be caused by the deleterious effects of aldosterone excess on the fibrosis and thickening of the arterial wall, mainly in the straight segments of vessels.
Citace poskytuje Crossref.org
The Effect of Primary Aldosteronism on Carotid Artery Texture in Ultrasound Images
Validation of Existing Clinical Prediction Tools for Primary Aldosteronism Subtyping
Long-term effect of specific treatment of primary aldosteronism on carotid intima-media thickness
