Increased intima-media thickness of the common carotid artery in primary aldosteronism in comparison with essential hypertension
Language English Country Netherlands Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
17563568
DOI
10.1097/hjh.0b013e3281268532
PII: 00004872-200707000-00022
Knihovny.cz E-resources
- MeSH
- Carotid Artery, Common diagnostic imaging pathology MeSH
- Echocardiography, Doppler MeSH
- Adult MeSH
- Hyperaldosteronism diagnostic imaging pathology MeSH
- Hypertension diagnostic imaging pathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Aged MeSH
- Tunica Intima diagnostic imaging pathology MeSH
- Tunica Media diagnostic imaging pathology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
BACKGROUND: Aldosterone contributes to the accumulation of collagen fibers and extracellular matrix in arterial wall. The aim of this study was to compare intima-media thickness (IMT) of the common carotid artery and carotid bifurcation in patients with primary aldosteronism, essential hypertension and healthy controls. METHODS: Carotid ultrasound studies were carried out in 33 patients aged 42-72 years with primary aldosteronism, 52 patients with essential hypertension and in 33 normotensive controls. RESULTS: The patients with primary aldosteronism had significantly higher IMT of the common carotid artery than patients with essential hypertension and controls (0.987 +/- 0.152 mm; 0.892 +/- 0.154 mm versus 0.812 +/- 0.124 mm; P < 0.001; P < 0.05). There was also significantly higher IMT of the common carotid in patients with essential hypertension compared to control group (0.892 +/- 0.154 mm versus 0.812 +/- 0.124 mm; P < 0.01). The differences between both hypertensive groups remained statistically significant after adjustment for age and 24-h systolic blood pressure (P = 0.001). The differences of the IMT in the carotid bifurcation were statistically significant only between patients with primary aldosteronism and controls (1.157 +/- 0.243 mm versus 0.994 +/- 0.199 mm; P <0.05). CONCLUSION: Patients with primary aldosteronism have increased common carotid IMT compared to the patients with essential hypertension. This finding could be caused by the deleterious effects of aldosterone excess on the fibrosis and thickening of the arterial wall, mainly in the straight segments of vessels.
References provided by Crossref.org
The Effect of Primary Aldosteronism on Carotid Artery Texture in Ultrasound Images
Validation of Existing Clinical Prediction Tools for Primary Aldosteronism Subtyping
Long-term effect of specific treatment of primary aldosteronism on carotid intima-media thickness
