Hysterectomy leads to fast improvement of haematological and immunological parameters in bitches with pyometra
Language English Country England, Great Britain Media print-electronic
Document type Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
17617161
DOI
10.1111/j.1748-5827.2007.00345.x
PII: JSAP345
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents therapeutic use MeSH
- Blood Chemical Analysis veterinary MeSH
- Hysterectomy veterinary MeSH
- Immunoglobulins blood MeSH
- Antigen-Antibody Complex blood MeSH
- Combined Modality Therapy MeSH
- Muramidase blood MeSH
- Uterine Diseases blood therapy veterinary MeSH
- Dog Diseases blood drug therapy surgery therapy MeSH
- Leukocyte Count MeSH
- Dogs MeSH
- Animals MeSH
- Check Tag
- Dogs MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Evaluation Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Immunoglobulins MeSH
- Antigen-Antibody Complex MeSH
- Muramidase MeSH
OBJECTIVES: To investigate whether a combination of hysterectomy and antibiotic treatment leads to an improvement of altered haematological and immunological parameters in bitches affected by pyometra. METHODS: Blood samples obtained from 13 bitches affected by pyometra were investigated before hysterectomy and seven days later for a total and differential leucocyte count, activity of neutrophils and lymphocytes, and quantification of total serum immunoglobulins, lysozyme and circulating immune complexes. RESULTS: The parameters most affected included changes in blood profile (leucocytosis because of neutrophilia or leucopenia) and inhibition of lymphocyte activity. Seven days after hysterectomy, all affected parameters returned to normal levels comparable to clinically healthy dogs. CLINICAL SIGNIFICANCE: Application of immunostimulating therapy is not necessary to manage changes in blood cell counts and suppression of lymphocyte activity in bitches with pyometra. Removal of the infected uterus, being the source of infection, leads to improvement.
References provided by Crossref.org
