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Poly(HEMA) hydrogels with controlled pore architecture for tissue regeneration applications

Studenovská, Hana
Author Studenovská, Hana Department of Bioanalogous and Special Polymers, Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06, Prague 6, Czech Republic. studenovska@imc.cas.cz
Slouf, Miroslav
Author Slouf, Miroslav
Rypácek, Frantisek
Author Rypácek, Frantisek

Journal of materials science. Materials in medicine. 2008 Feb ; 19 (2) : 615-21. [epub] 20070710

J Mater Sci Mater Med
ISSN 0957-4530
Source

Language English Country United States Media print-electronic

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link https://www.medvik.cz/link/pmid17619953

PubMed 17619953
DOI 10.1007/s10856-007-3217-0
Knihovny.cz E-resources

MeSH
Biocompatible Materials chemistry MeSH
Hydrogels chemistry MeSH
Microscopy, Electron, Scanning MeSH
Polyamines chemistry MeSH
Polyhydroxyethyl Methacrylate analogs & derivatives chemistry MeSH
Guided Tissue Regeneration * MeSH
Publication type
Journal Article MeSH
Research Support, Non-U.S. Gov't MeSH
Names of Substances
Biocompatible Materials MeSH
Hydrogels MeSH
poly(2-hydroxyethyl methacrylate)-polyamine graft copolymer MeSH Browser
Polyamines MeSH
Polyhydroxyethyl Methacrylate MeSH

The technique for fabrication of soft porous hydrogels, in which both the size and the orientation of inner pores can be controlled, was developed. Three-dimensional hydrophilic gels based on poly[2-hydroxyethyl methacrylate] are designed as scaffolds for regeneration of soft tissues, e.g., nerve tissue. Anisotropic macropores of the size ranging from 10 to 50 microm were formed (1) by using a porogen-leaching method with a solid organic porogen, (2) by phase-separation during gelation in solvent-nonsolvent mixture, or (3) by combination of solid porogen elimination and phase-separation. As a porogen, poly(L-lactide) fibers were applied and consequently washed away under mild conditions to obtain desired spatial orientation of pores. Highly water-swollen polymer gels were characterized with high pressure (low vacuum) scanning electron microscopy (AquaSEM). The morphology of voids remaining after removing the solid PLLA porogen (the macropores) was clearly shown.

Department of Bioanalogous and Special Polymers Institute of Macromolecular Chemistry Academy of Sciences of the Czech Republic Heyrovsky Sq 2 162 06 Prague 6 Czech Republic

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