Improved control of hypertension in children after renal transplantation: results of a two-yr interventional trial
Jazyk angličtina Země Dánsko Médium print
Typ dokumentu klinické zkoušky, časopisecké články, práce podpořená grantem
PubMed
17631016
DOI
10.1111/j.1399-3046.2006.00661.x
PII: PTR661
Knihovny.cz E-zdroje
- MeSH
- ambulantní monitorování krevního tlaku MeSH
- antihypertenziva terapeutické užití MeSH
- časové faktory MeSH
- chronické selhání ledvin chirurgie MeSH
- cirkadiánní rytmus MeSH
- dítě MeSH
- hypertenze farmakoterapie etiologie patofyziologie MeSH
- krevní tlak účinky léků fyziologie MeSH
- lidé MeSH
- mladiství MeSH
- následné studie MeSH
- předškolní dítě MeSH
- prospektivní studie MeSH
- průřezové studie MeSH
- transplantace ledvin škodlivé účinky MeSH
- výsledek terapie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- předškolní dítě MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antihypertenziva MeSH
Hypertension is a frequent complication in children after renal transplantation and the control of post-transplant hypertension is unsatisfactorily low. The aim of this prospective interventional study was to improve the control of hypertension in children after renal transplantation. Thirty-six children fulfilled the inclusion criteria (> or =6 months after transplantation and no acute rejection in the last three months). BP was measured using ABPM. Hypertension was defined as mean ambulatory BP > or =95th-centile for healthy children and/or using antihypertensive drugs. The study intervention consisted of using intensified antihypertensive drug therapy - in children with uncontrolled hypertension (i.e., mean ambulatory BP was > or =95th centile in treated children), antihypertensive therapy was intensified by adding new antihypertensive drugs to reach goal BP <95th centile. ABPM was repeated after 12 and 24 months. Daytime BP did not change significantly after 12 or 24 months. Night-time BP decreased from 1.57 +/- 1.33 to 0.88 +/- 0.84 SDS for systolic and from 1.10 +/- 1.51 to 0.35 +/- 1.18 SDS for diastolic BP after 24 months (p < 0.05). The number of antihypertensive drugs increased from 2.1 +/- 0.9 to 2.7 +/- 0.8 drugs per patient (p < 0.05), this was especially seen with the use of ACE-inhibitors (increase from 19% to 40% of children, p < 0.05). In conclusion, this interventional trial demonstrated that, in children after renal transplantation, the control of hypertension, especially at night-time, can be improved by increasing the number of antihypertensive drugs, especially ACE-inhibitors.
Citace poskytuje Crossref.org
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