What is the neural substrate of our capability to properly react to changes in the environment? It can be hypothesized that the anterior cingulate cortex (ACC) manages repetitive stimuli in routine conditions and alerts the dorsolateral prefrontal cortex (PFC) when stimulation unexpectedly changes. To provide evidence in favor of this hypothesis, intracerebral stereoelectroencephalographic (SEEG) data were recorded from the anterior cingulate and dorsolateral PFC of eight epileptic patients in a standard visual oddball task during presurgical monitoring. Two types of stimuli (200 ms duration) such as the letters O (frequent stimuli; 80% of probability) and X (rare stimuli) were presented in random order, with an interstimulus interval between 2 and 5 s. Subjects had to mentally count the rare (target) stimuli and to press a button with their dominant hand as quickly and accurately as possible. EEG frequency bands of interest were theta (4-8 Hz), alpha (8-12 Hz), beta (14-30 Hz), and gamma (30-45 Hz). The directionality of the information flux within the EEG rhythms was indexed by a directed transfer function (DTF). The results showed that compared with the frequent stimuli, the target stimuli induced a statistically significant increase of DTF values from the anterior cingulate to the dorsolateral PFC at the theta rhythms (P < 0.01). These results provide support to the hypothesis that ACC directly or indirectly affects the oscillatory activity of dorsolateral PFC by a selective frequency code under typical oddball conditions.

1st Department of Neurology Masaryk University St Anne's Hospital Brno Czech Republic

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Babiloni C,Babiloni F,Carducci F,Cincotti F,Vecchio F,Cola B,Rossi S,Miniussi C,Rossini PM( 2004): Functional frontoparietal connectivity during short‐term memory as revealed by high‐resolution EEG coherence analysis. Behav Neurosci 118: 687–697. PubMed

Babiloni C,Vecchio F,Cappa S,Pasqualetti P,Rossi S,Miniussi C,Rossini PM( 2006): Functional frontoparietal connectivity during encoding and retrieval processes follows HERA model. A high‐resolution study. Brain Res Bull 68: 203–212. PubMed

Banich MT,Milham MP,Atchley RA,Cohen NJ,Webb A,Wszalek T,Kramer AF,Liang Z,Barad V,Gullet D,Shah C,Brown C( 2000): Prefrontal regions play a predominant role in imposing an attentional “set”: Evidence from fMRI. Cogn Brain Res 10: 1–9. PubMed

Barbas H,Pandya DN( 1989): Architecture and intrinsic connections of the prefrontal cortex in the rhesus monkey. J Comp Neurol 286: 353–375. PubMed

Barch DM,Braver TS,Akbudak E,Conturo T,Ollinger J,Snyder A( 2001): Anterior cingulate cortex and response conflict: Effects of response modality and processing domain. Cereb Cortex 11: 837–848. PubMed

Basar E,Basar‐Eroglu C,Karakas S,Schurmann M( 1999): Are cognitive processes manifested in event‐related gamma, α, θ and δ oscillations in the EEG? Neurosci Lett 259: 165–168. PubMed

Baudena P,Halgren E,Heit G,Clarke JM( 1995): Intracerebral potentials to rare target and distractor auditory and visual stimuli. III. Frontal cortex. Electroencephalogr Clin Neurophysiol 94: 251–264. PubMed

Berg RW,Kleinfeld D( 2003): Vibrissa movement elicited by rhythmic electrical microstimulation to motor cortex in the aroused rat mimics exploratory whisking. J Neurophysiol 90: 2950–2963. PubMed

Blinowska KJ,Kus R,Kaminski M. 2004): Granger causality and information flow in multivariate processes. Phys Rev E Stat Nonlin Soft Matter Phys 70(5, Part 1): 050902. PubMed

Botvinick M,Nystrom LE,Fissell K,Carter CS,Cohen JD( 1999): Conflict monitoring versus selection‐for‐action in anterior cingulate cortex. Nature 402: 179–181. PubMed

Brankack J,Seidenbecher T,Muller‐Gartner HW( 1996): Task‐relevant late positive component in rats: is it related to hippocampal θ rhythm? Hippocampus 6: 475–482. PubMed

Braver TS,Barch DM,Kelley WM,Buckner RL,Cohen NJ,Miezin FM,Snyder AZ,Ollinger JM,Akbudak E,Conturo TE,Petersen SE( 2001): Direct comparison of prefrontal cortex regions engaged by working and long‐term memory tasks. Neuroimage 14: 48–59. PubMed

Brázdil M,Rektor I,Dufek M,Daniel P,Jurák P,Kuba R( 1999): The role of frontal and temporal lobes in visual discrimination task—Depth ERP studies. Neurophysiol Clin 29: 339–350. PubMed

Brázdil M,Dobšík M,Mikl M,Hluštík P,Daniel P,Pažourková M,Krupa P,Rektor I( 2005): Combined event‐related fMRI and intracerebral ERP study of an auditory oddball task. Neuroimage 26/1: 285–293. PubMed

Brázdil M,Mikl M,Mareček R,Krupa P,Rektor I.( 2007): Effective connectivity in target stimulus processing: A dynamic causal modeling study of visual oddball task. NeuroImage 35: 827–835. PubMed

Bush G,Luu P,Posner MI( 2000): Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci 4: 215–222. PubMed

Buzsaki G,Draguhn A( 2004): Neuronal oscillations in cortical networks. Science 304: 1926–1929. PubMed

Carter CS,Braver TS,Barch DM,Botvinick MM,Noll D,Cohen JD( 1998): Anterior cingulate cortex, error detection, and the online monitoring of performance. Science 280: 747–749. PubMed

Clark VP,Fannon S,Lai S,Benson R,Bauer L( 2000): Responses to rare visual target and distractor stimuli using event‐related fMRI. J Neurophysiol 83: 3133–3139. PubMed

Cohen JD,Botvinick M,Carter CS( 2000): Anterior cingulate and prefrontal cortex: Who's in control? Nat Neurosci 3: 421–423. PubMed

Corbetta M,Shulman GL( 2002): Control of goal‐directed and stimulus‐driven attention in the brain. Nat Rev Neurosci 3: 201–215. PubMed

De Gennaro L,Vecchio F,Ferrara M,Curcio G,Rossini PM,Babiloni C( 2004): Changes in fronto‐posterior functional coupling at sleep onset in humans. J Sleep Res 13: 209–217. PubMed

Fan J,McCandliss BD,Fossella J,Flombaum JI,Posner MI( 2005): The activation of attentional networks. Neuroimage 26: 471–479. PubMed

Gevins A,Smith ME( 2000): Neurophysiological measures of working memory and individual differences in cognitive ability and cognitive style. Cereb Cortex 10: 829–839. PubMed

Gitelman DR,Nobre AC,Parrish TB,LaBar KS,Kim YH,Meyer JR,Mesulam MM( 1999): A large‐scale distributed network for covert spatial attention: Further anatomical delineation based on stringent behavioral and cognitive controls. Brain 122: 1093–1106. PubMed

Halgren E,Marinkovic K,Chauvel P( 1998): Generators of the late cognitive potentials in auditory and visual oddball tasks. Electroencephalogr Clin Neurophysiol 106: 156–164. PubMed

Hasselmo ME,Hay J,Ilyn M,Gorchetchnikov A( 2002): Neuromodulation, θ rhythm and rat spatial navigation. Neural Netw 15: 689–707. PubMed

Kaminski MJ,Blinowska KJ( 1991): A new method of the description of the information flow in the structures. Biol Cybern 65: 203–210. PubMed

Kaminski MJ,Blinowska KJ,Szclenberger W( 1997): Topographic analysis of coherence and propagation of EEG activity during sleep and wakefulness. Electroencephalogr Clin Neurophysiol 102: 216–227. PubMed

Kiehl KA,Laurens KR,Duty TL,Forster BB,Liddle PF( 2001): Neural sources involved in auditory target detection and novelty processing: An event‐related fMRI study. Psychophysiology 38: 133–142. PubMed

Kiehl KA,Stevens MC,Laurens KR,Pearlson G,Calhoun VD,Liddle PF( 2005): An adaptive reflexive processing model of neurocognitive function: Supporting evidence from a large scale (n = 100) fMRI study of an auditory oddball task. Neuroimage 25: 899–915. PubMed

Kleinfeld D,Berg RW,O'Connor SM( 1999): Anatomical loops and their electrical dynamics in relation to whisking by rat. Somatosens Mot Res 16: 69–88. PubMed

Klimesch W( 1999): EEG α and θ oscillations reflect cognitive and memory performance: A review and analysis. Brain Res Brain Res Rev 29: 169–195. PubMed

Klimesch W,Doppelmayr M,Yonelinas A,Kroll NE,Lazzara M,Rohm D,Gruber W( 2001): θ Synchronization during episodic retrieval: Neural correlates of conscious awareness. Brain Res Cogn Brain Res 12: 33–38. PubMed

Klimesch W,Doppelmayr M,Hanslmayr S( 2006): Upper α ERD and absolute power: Their meaning for memory performance. Prog Brain Res 159: 151–165. PubMed

Kondo H,Osaka N,Osaka M( 2004): Cooperation of the anterior cingulate cortex and dorsolateral prefrontal cortex for attention shifting. Neuroimage 23: 670–679. PubMed

Konrad K,Neufang S,Thiel CM,Specht K,Hanisch C,Fan J,Herpertz‐Dahlmann B,Fink GR( 2005): Development of attentional networks: An fMRI study with children and adults. Neuroimage 28: 429–439. PubMed

Luks TL,Simpson GV,Feiwell RJ,Miller WL( 2002): Evidence for anterior cingulate cortec involvement in monitoring preparatory attentional set. NeuroImage 17: 792–802. PubMed

MacDonald AW,Cohen JD,Stenger VA,Carter CS( 2000): Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. Science 288: 1835–1838. PubMed

Mesulam MM( 1981): A cortical network for directed attention and unilateral neglect. Ann Neurol 10: 309–325. PubMed

Mesulam MM( 1990): Large‐scale neurocognitive networks and distributed processing for attention, language, and memory. Ann Neurol 28: 597–613. PubMed

Mesulam MM( 1999): Spatial attention and neglect: parietal, frontal and cingulate contributions to the mental representation and attentional targeting of salient extrapersonal events. Philos Trans R Soc London 354: 1325–1346. PubMed PMC

Milham MP,Banich MT,Claus ED,Cohen NJ( 2003): Practice‐related effects demonstrate complementary roles of anterior cingulate and prefrontal cortices in attentional control. Neuroimage 18: 483–493. PubMed

Nebel K,Wiese H,Stude P,de Greiff A,Diener HC,Keidel M( 2005): On the neural basis of focused and divided attention. Cogn Brain Res 25: 760–776. PubMed

Pfurtscheller G,Lopes da Silva FH( 1999): Event‐related EEG/MEG synchronization and desynchronization: Basic principles. Clin Neurophysiol 110: 1842–1857. PubMed

Sauseng P,Klimesch W,Gruber WR,Doppelmayr M,Stadler M,Schabus M( 2002): The interplay between θ and α oscillations in the human electroencephalogram reflects the transfer of information between memory systems. Neurosci Lett 323: 121–124. PubMed

Sauseng P,Klimesch W,Doppelmayr M,Hanslmayr S,Schabus M,Gruber WR( 2004): θ Coupling in the human electroencephalogram during a working memory task. Neurosci Lett 354: 123–126. PubMed

Shallice T( 1988): From Neuropsychology to Mental Structure. Cambridge: Cambridge University Press.

Shallice T,Burgess PW,Schon F,Baxter DM( 1989): The origin of utilization behavior. Brain 112: 1587–1598. PubMed

Snyder E,Hillyard SA( 1976): Long‐latency evoked potentials to irrelevant, deviant stimuli. Behav Biol 16: 319–331. PubMed

Sochůrková D,Brázdil M,Jurák P,Rektor I( 2006): P3 and ERD/ERS in a visual oddball paradigm. A depth EEG study from the mesial temporal structures. J Psychophysiol 20: 32–39.

Squires NK,Squires KC,Hillyard SA( 1975): Two varieties of long‐latency positive waves evoked by unpredictable auditory stimuli in man. Electroencephalogr Clin Neurophysiol 38: 387–401. PubMed

Stevens AA,Skudlarski P,Gatenby JC,Gore JC( 2000): Event‐related fMRI of auditory and visual oddball tasks. Magn Reson Imaging 18: 495–502. PubMed

Talairach J,Szikla G,Tournoux P,Prosalentis A,Bordas‐Ferrer M,Covello J( 1967): Atlas d'anatomie stereotactique du telencephale. Paris: Masson;

Vanderwolf CH( 1969): Hippocampal electrical activity and voluntary movement in the rat. Electroencephalogr Clin Neurophysiol 26: 407–418. PubMed

Verleger R,Jaskowski P,Wascher E( 2005): Evidence for an integrative role of P3b in linking reaction to perception. J Psychophysiol 19: 165–181.

Whishaw IQ,Schallert T( 1977): Hippocampal RSA (θ), apnea, bradycardia and effects of atropine during underwater swimming in the rat. Electroencephalogr Clin Neurophysiol 42: 389–396. PubMed

Woldorf MG,Fichtenholtz HM,Song AW,Mangun GR. 2001): Cue‐ and target‐related processing in a fast‐rate cued visual spatial attention paradigm. Presented at the 2001 Meeting of the Organization for Human Brain Mapping. Brighton,UK.

Yoshiura T,Zhong J,Shibata DK,Kwok WE,Shrier DA,Numaguchi Y( 1999): Functional MRI study of auditory and visual oddball tasks. Neuroreport 10: 1683–1688. PubMed

Altered directed functional connectivity of the right amygdala in depression: high-density EEG study

On the time course of synchronization patterns of neuronal discharges in the human brain during cognitive tasks