Highly lipophilic benzoxazoles with potential antibacterial activity
Language English Country Switzerland Media electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18007347
PubMed Central
PMC6147629
DOI
10.3390/10070783
PII: 10070783
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Antifungal Agents pharmacology MeSH
- Antitubercular Agents pharmacology MeSH
- Benzoxazoles chemistry pharmacology MeSH
- Isomerism MeSH
- Isoniazid pharmacology MeSH
- Molecular Conformation MeSH
- Models, Molecular MeSH
- Mycobacterium tuberculosis drug effects MeSH
- Solubility MeSH
- Structure-Activity Relationship MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Antifungal Agents MeSH
- Antitubercular Agents MeSH
- Benzoxazoles MeSH
- Isoniazid MeSH
A series of lipophilic 2-substituted 5,7-di-tert-butylbenzoxazoles was prepared in average yields by the reaction of 3,5-di-tert-butyl-1,2-benzoquinone with amino acids and dipeptides bearing N-terminal glycine. Dipeptides having other N-terminal amino acids undergo oxidative deamination. 5,7-Di-tert-butylbenzoxazoles have shown activity against Mycobacterium tuberculosis and some nontuberculous strains where isoniazid has been inactive. Antifungal activity was mediocre.
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